news from the crcm

2 June 2026

CDK1 phosphorylation switches SLX4 SAP from DNA binding to MUS81 binding

Scaglione and Gaillard show that the SLX4 SAP domain selectively binds four-way branched DNA structures. Their findings identify CDK1 phosphorylation as a molecular switch that inhibits DNA binding while promoting MUS81 interaction, thereby temporally controlling distinct SAP functions.
10 April 2026

Understanding EZH2 activities in leukemia, a potential therapeutic strategy

Our research is funded by INCA and the Japanese company ASPIRE as part of a Franco-Japanese collaborative program aimed at improving our understanding of the mechanisms underlying the dysregulation of the EZH2 enzyme in leukemia. Our goal is to shed light on the regulatory mechanisms of EZH2’s oncogenic activity, which could serve as a therapeutic target.