10 April 2026

Understanding EZH2 activities in leukemia, a potential therapeutic strategy

Our research is funded by INCA and the Japanese company ASPIRE as part of a Franco-Japanese collaborative program aimed at improving our understanding of the mechanisms underlying the dysregulation of the EZH2 enzyme in leukemia. Our goal is to shed light on the regulatory mechanisms of EZH2’s oncogenic activity, which could serve as a therapeutic target.
28 January 2025

De Sepulveda team reveals kinase inactivity of MAN2A1-FER oncoprotein: tyrosine kinase inhibitors called into question

Published in Cellular and Molecular Gastroenterology and Hepatology, the De Sepulveda team's study demonstrates that the MAN2A1-FER oncoprotein, present in several cancers, lacks kinase activity, calling into question the efficacy of tyrosine kinase inhibitors as a therapeutic strategy.