The Department of Genome Integrity, headed by Drs Bertrand LLorente and Pierre-Henri Gaillard, investigates the fundamental mechanisms that maintain genome stability through DNA replication, repair and recombination, and how their disruption contributes to cancer development.

With a solid foundation in basic research, the department also builds translational programmes to advance oncology. Its six research teams combine a variety of biological models and scientific approaches to support a continuum from basic discoveries to potential clinical applications.

The department is also strongly committed to training the next generation of scientists in state-of-the-art techniques with an overarching mission to deepen our understanding of genome maintenance mechanisms and their implications for cancer biology and treatment.