Archives des Genome Integrity Department

2 June 2026

CDK1 phosphorylation switches SLX4 SAP from DNA binding to MUS81 binding

Scaglione and Gaillard show that the SLX4 SAP domain selectively binds four-way branched DNA structures. Their findings identify CDK1 phosphorylation as a molecular switch that inhibits DNA binding while promoting MUS81 interaction, thereby temporally controlling distinct SAP functions.

6 May 2026

Recent Publications

Publications by the CRCM teams in recent weeks.

29 April 2026

Article interview Christophe De La Roche André - Quand les chromosomes change la donne

29 April 2026

When an extra chromosome changes the game

Christophe DE LA ROCHE SAINT ANDRÉ A passionate researcher, dedicated educator, and well-known figure at […]

31 March 2026

31 PhD positions available at CRCM: discover research opportunities in cancer research

CRCM offers 31 PhD projects covering a wide range of topics in cancer research. These projects are proposed within the doctoral schools ED658 and ED659 and are accessible through their competitive selection process.

28 January 2025

New 2025 label for the Ligue Nationale Contre le Cancer (National League Against Cancer)

The "Control of structure-specific endonucleases and genome stability" team (Gaillard team) is proud to receive support from the Ligue Nationale Contre le Cancer.

28 January 2025

Recent publications from the Modesti team: new perspectives on DNA repair and NHEJ

Recent publications by the Modesti team in Nat. Struct. Mol. Biol. and Nucleic Acids Res. reveal new DNA repair mechanisms, highlighting the role of disordered regions of XRCC4/XLF and the impact of Lig3 and Lig4 on cell viability.

28 January 2025

Coulon team identifies heterozygous RPA2 variant as new cause of telomere biology disorders

Published in Genes & Development, the Coulon team's study identifies a heterozygous variant of RPA2 as a new cause of disorders in telomere biology, impacting their stability and regulation.

28 January 2025

The Telomeres and Chromatin group (Coulon team) joins the MarMaRa Institute

The MarMaRa Institute, which brings together over 30 interdisciplinary research teams, now welcomes the Telomeres and Chromatin team. This partnership will strengthen research into rare diseases, combining genetics, systems biology and therapeutic innovations to improve diagnosis and treatment.

10 January 2025

Christophe Lachaud organizes a solidarity karaoke evening at the Blackstone

Organized by Christophe Lachaud, the evening raised funds for the IPC, supporting the CRCM/IOC in their fight against cancer. A great success, combining solidarity and conviviality.

31 December 2024

Funding to study DNA replication gaps and replication block

Thanks to support from Cancéropole PACA, Luisa Laureti from the Pagès team is studying how single-strand DNA breaks are repaired during replication stalling, a key to a better understanding of cancers.

31 December 2024

ARC funding to shed light on the mysteries of DNA repair

The project entitled "How single-strand DNA gaps control the balance between faithful and mutagenic pathways of lesion tolerance" (Pagès team) has recently been awarded a three-year grant from the ARC Foundation.

3 December 2024

Preprints and recent submissions from the Modesti team: promising work undergoing validation

Discover the latest research from the Modesti team, currently being evaluated by the scientific community. These studies explore key mechanisms of DNA repair and cell regulation.