2 June 2026

CDK1 phosphorylation switches SLX4 SAP from DNA binding to MUS81 binding

Scaglione and Gaillard show that the SLX4 SAP domain selectively binds four-way branched DNA structures. Their findings identify CDK1 phosphorylation as a molecular switch that inhibits DNA binding while promoting MUS81 interaction, thereby temporally controlling distinct SAP functions.
11 April 2025

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