news from the crcm

28 January 2025

De Sepulveda team reveals kinase inactivity of MAN2A1-FER oncoprotein: tyrosine kinase inhibitors called into question

Published in Cellular and Molecular Gastroenterology and Hepatology, the De Sepulveda team's study demonstrates that the MAN2A1-FER oncoprotein, present in several cancers, lacks kinase activity, calling into question the efficacy of tyrosine kinase inhibitors as a therapeutic strategy.
28 January 2025

The Chames team deciphers the interaction between immune response and the efficiency of immune cell engagers

Published in ACS Nano, the study deciphers the impact of biophysical parameters and individual immune response on the efficacy of immune cell engagers, paving the way for optimizing their design in immunotherapy.