news from the crcm

28 January 2025

Recent publications from the Modesti team: new perspectives on DNA repair and NHEJ

Recent publications by the Modesti team in Nat. Struct. Mol. Biol. and Nucleic Acids Res. reveal new DNA repair mechanisms, highlighting the role of disordered regions of XRCC4/XLF and the impact of Lig3 and Lig4 on cell viability.
28 January 2025

The Telomeres and Chromatin group (Coulon team) joins the MarMaRa Institute

The MarMaRa Institute, which brings together over 30 interdisciplinary research teams, now welcomes the Telomeres and Chromatin team. This partnership will strengthen research into rare diseases, combining genetics, systems biology and therapeutic innovations to improve diagnosis and treatment.
28 January 2025

The 1st edition of SOUTH-ROCK’s WORKING DAYS

SouthROCK is a consortium of excellence dedicated to pediatric cancer research, bringing together 250 experts from Lyon and Marseille. Its multidisciplinary work aims to accelerate scientific advances, improve care and prevent the side effects of treatment for sick children.
28 January 2025

De Sepulveda team reveals kinase inactivity of MAN2A1-FER oncoprotein: tyrosine kinase inhibitors called into question

Published in Cellular and Molecular Gastroenterology and Hepatology, the De Sepulveda team's study demonstrates that the MAN2A1-FER oncoprotein, present in several cancers, lacks kinase activity, calling into question the efficacy of tyrosine kinase inhibitors as a therapeutic strategy.
28 January 2025

The Chames team deciphers the interaction between immune response and the efficiency of immune cell engagers

Published in ACS Nano, the study deciphers the impact of biophysical parameters and individual immune response on the efficacy of immune cell engagers, paving the way for optimizing their design in immunotherapy.