10 February 2025
This publication in Cell reveals how two distinct E3 ligases target BACH1 quaternary degrons under oxidative stress, in collaboration with several research teams.
28 January 2025
Recent publications by the Modesti team in Nat. Struct. Mol. Biol. and Nucleic Acids Res. reveal new DNA repair mechanisms, highlighting the role of disordered regions of XRCC4/XLF and the impact of Lig3 and Lig4 on cell viability.
28 January 2025
Published in Genes & Development, the Coulon team's study identifies a heterozygous variant of RPA2 as a new cause of disorders in telomere biology, impacting their stability and regulation.
28 January 2025
Published in Cellular and Molecular Gastroenterology and Hepatology, the De Sepulveda team's study demonstrates that the MAN2A1-FER oncoprotein, present in several cancers, lacks kinase activity, calling into question the efficacy of tyrosine kinase inhibitors as a therapeutic strategy.
28 January 2025
Published in ACS Nano, the study deciphers the impact of biophysical parameters and individual immune response on the efficacy of immune cell engagers, paving the way for optimizing their design in immunotherapy.
3 December 2024
Discover the latest research from the Modesti team, currently being evaluated by the scientific community. These studies explore key mechanisms of DNA repair and cell regulation.