Keywords: DNA repair, DNA damage, translesional synthesis (TLS), homologous recombination (HR), mutagenesis, Saccharomyces cerevisiae.

About the laboratory:
The Centre de Recherche en Cancérologie de Marseille (CRCM) is located within the Institut Paoli-Calmettes, a comprehensive institute dedicated to the fight against cancer. Its aim is to improve knowledge of cancer biology and medicine through a continuum of fundamental, translational and clinical research.

The “DNA Damage and Genome Instability” team, led by Dr Vincent Pagès, is part of CRCM’s “Genome Integrity” department. This team aims to understand the biological consequences of damaged genome replication, which is the main source of point mutations and the initial cause of cancer. Recently, Dr. Pagès’ team developed a new method for introducing a single lesion into the genome of a living cell(bacteria and yeast), in order to monitor the fate of this lesion in vivo.

The aim of the proposed postdoctoral research project is to explore the genetic and molecular mechanisms of DNA damage tolerance pathways in the yeast Saccharomyces cerevisiae.

Profile required:
The candidate must hold a PhD in molecular biology or a related field, and must have knowledge of DNA damage. Experience in yeast genetics is recommended but not mandatory.

Position:
The position is currently open and funded for 2.5 years by a grant from the ARC Foundation. With the full support of the team leader, the candidate is also encouraged to apply for his/her own funding.

Contact:
A CV and covering letter should be sent to Vincent Pagès: vincent.pages@cnrs.fr.