In order to discover therapeutic targets and biomarkers, our team makes use of last advances in high resolution mass spectrometry to characterize proteins at the surface of cancer cells and pinpoint isoforms or post-translational modifications linked to cancer progression, resistance and relapse. An ambitious technological development focuses on single cell proteomics analysis to access tumor heterogeneity in xenografts, tumoroids and human biopsies.
We have a long expertise in the characterization of G protein-coupled receptors (GPCRs), highly druggable proteins which represent the targets of more than 35% of drugs used in clinics but are still underexploited in the field of cancer.
Generation of in-house nanobodies/antibodies against candidate proteins will push further the characterization in larger cohorts and hopefully produce immunopharmacological tools to correct GPCRs activity in cancer cells or drive targeted therapeutics.
Our team received support from the French government under the France 2030 investment plan, as part of the “Initiative d’Excellence d’Aix-Marseille Université – AMIDEX” AMX-23-CEC-02.
The projects
Our team holds several on-going grants from the French Agency for Research (ANR) on projects aiming at characterizing the regulation of membrane proteins affected in human diseases.
Team news
Featured publications
01/2024
Philibert CE, Disdier C, Lafon PA, Bouyssou A, Oosterlaken M, Galant S, Pizzoccaro A, Tuduri P, Ster J, Liu J, Kniazeff J, Pin JP, Rondard P, Marin P, Vandermoere F.
04/2023
Schlotter F, Mérouani S, Flayac J, Kogey V, Issa A, Dodré M, Huttin A, Branlant C, Bertrand E, Labialle S, Vandermoere F, Verheggen C, Massenet S.
07/2022
Dos Santos Morais R, Santo PE, Ley M, Schelcher C, Abel Y, Plassart L, Deslignière E, Chagot ME, Quinternet M, Paiva ACF, Hessmann S, Morellet N, M F Sousa P, Vandermoere F, Bertrand E, Charpentier B, Bandeiras TM, Plisson-Chastang C, Verheggen C, Cianférani S, Manival X
06/2021
Klimešová K, Vojáčková J, Radivojević N, Vandermoere F, Bertrand E, Verheggen C, Staněk D
06/2018
Murat S, Bigot M, Chapron J, König GM, Kostenis E, Battaglia G, Nicoletti F, Bourinet E, Bockaert J, Marin P, Vandermoere F
