{"id":12525,"date":"2026-06-15T11:31:28","date_gmt":"2026-06-15T09:31:28","guid":{"rendered":"https:\/\/crcm-marseille.fr\/uncategorized\/crl2-fem1b-uses-heme-to-recruit-bach1-for-degradation-and-regulate-ferroptosis-in-lung-cancer\/"},"modified":"2026-06-15T11:35:23","modified_gmt":"2026-06-15T09:35:23","slug":"crl2-fem1b-uses-heme-to-recruit-bach1-for-degradation-and-regulate-ferroptosis-in-lung-cancer","status":"publish","type":"post","link":"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/crl2-fem1b-uses-heme-to-recruit-bach1-for-degradation-and-regulate-ferroptosis-in-lung-cancer\/","title":{"rendered":"CRL2-FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer"},"content":{"rendered":"\n<p><strong>How does a cell sense heme and translate this signal into a stress response?<\/strong><\/p>\n\n<p>The Lignitto laboratory discovered that the redox-sensing metabolite heme directly enables the recognition of BACH1 by CRL2\u2013FEM1B. Rather than simply binding BACH1, heme creates the interface required for FEM1B recruitment and BACH1 degradation. Remarkably, this mechanism shares key features with molecular glue degraders, providing some of the first evidence that an endogenous metabolite can directly promote substrate\u2013E3 ligase interactions in mammalian cells.  <\/p>\n\n<p>By controlling BACH1 stability, this pathway regulates ferroptosis sensitivity in lung cancer cells, highlighting a previously unrecognized vulnerability that could be therapeutically exploited.<\/p>\n\n<p>These findings open new avenues for the development of BACH1-targeting degraders and ferroptosis-based cancer therapies.<\/p>\n\n<p>Ahmed B, Salaun D, Jordan JB, Daulat A, Pastorello C, Brito T, Yang Y, Josselin E, Byrne D, Betzi S, Pelletier A, Vernerey J, Ferreira L, Castellano R, Audebert S, Camoin L, Pane A, Bechara C, Borg JP, Modesti M, Lignitto L. <a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(26)00242-X\" type=\"link\" id=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(26)00242-X\">CRL2<sup>FEM1B<\/sup> uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer.<\/a> Mol Cell. 2026 May 21;86(10):1993-2011.e10. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this study, the Lignitto laboratory at CRCM identifies the E3 ubiquitin ligase CRL2\u2013FEM1B as a key regulator of redox homeostasis and ferroptosis through the degradation of the transcription factor BACH1.<\/p>\n","protected":false},"author":3,"featured_media":12523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"categories":[212,205],"tags":[],"class_list":["post-12525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lignitto-team","category-crcm-articles"],"yoast_head":"<!-- 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degradation of the transcription factor BACH1.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/crl2-fem1b-uses-heme-to-recruit-bach1-for-degradation-and-regulate-ferroptosis-in-lung-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"CRCM\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-15T09:31:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-15T09:35:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2026\/06\/CRL2.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"333\" \/>\n\t<meta property=\"og:image:height\" content=\"198\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"L\u00e9a Girard\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L\u00e9a Girard\" 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