{"id":5943,"date":"2024-12-30T15:12:46","date_gmt":"2024-12-30T14:12:46","guid":{"rendered":"https:\/\/crcm-marseille.fr\/our-technology-platforms\/immunomonitoring-platform\/"},"modified":"2025-11-18T10:31:09","modified_gmt":"2025-11-18T09:31:09","slug":"immunomonitoring","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/","title":{"rendered":"Immunomonitoring"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring\/#\"><\/a><\/li>\n<\/ul>\n\n<h1 class=\"wp-block-heading\">Immunomonitoring<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/x.com\/tumimmuno_crcm\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-sophie-chretien\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/anne_sophie_chretien_crcm.jpg\" alt=\"Anne-Sophie Chr&#xE9;tien - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-sophie-chretien\/\">Anne-Sophie Chr\u00e9tien<\/a><\/p>\n\n<p>Platform Manager<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/daniel-olive\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/daniel-olive-140x140-2.jpg\" alt=\"Daniel Olive - Immunity and Cancer Team - CRCM - Cytometry Platform - Immunomonitoring Platform\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/daniel-olive\/\">Daniel Olive<\/a><\/p>\n\n<p>Platform Manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/teo-fernez\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/teo-fernez\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/fernez_teo_crcm.jpg\" alt=\"Fernez T&#xE9;o - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">T\u00e9o Fernez<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/theo-wirth\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/theo-wirth\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/wirth_theo_crcm.jpg\" alt=\"Wirth Th&#xE9;o - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Th\u00e9o Wirth<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=3291\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yara-rym-el-hawly\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Yara-rym-el-Hawly_crcm.jpg\" alt=\"Yara Rym El-Hawly\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yara Rym El-Hawly<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/amira-ben-amara\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/amira-ben-amara\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/ben_amara_amira_crcm.jpg\" alt=\"Ben amara Ben Hadid Amira - Immunity and Cancer Team - CRCM - Immunomonitoring Platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Amira Ben Amara<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/diane-rattier\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/diane-rattier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/rattier_diane_crcm.jpg\" alt=\"Rattier Diane - Marseille Cancer Research Center - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Diane Rattier<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/emilien-billon\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/emilien-billon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Emilien-Billon.jpg\" alt=\"Emilien Billon\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Emilien Billon<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral Hospital Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/laurent-gorvel-2\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/laurent-gorvel-2\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/gorvel_laurent_crcm.jpg\" alt=\"Gorvek Laurent - - Immunity and Cancer Team - CRCM - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Laurent Gorvel<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lucie-robert\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lucie-robert\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/robert_lucie_crcm.jpg\" alt=\"Robert Lucie - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Lucie Robert<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-sarah-rouviere\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-sarah-rouviere\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Marie-Sarah-Rouviere_crcm.jpg\" alt=\"Rouvi&#xE8;re Marie_Sarah - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marie-Sarah Rouviere<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/nicolas-boucherit\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/nicolas-boucherit\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/boucherit_nicolas_crcm.jpg\" alt=\"Boucherit Nicolas - Marseille Cancer Research Center - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Nicolas Boucherit<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=2426\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/pauline-maby\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Pauline Maby\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Pauline Maby<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/philippe-livrati\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/philippe-livrati\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/livratit_-philippe_crcm.jpg\" alt=\"Livratit Philippe - Marseille Cancer Research Center - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Philippe Livrati<\/h2>\n\n<h4 class=\"wp-block-heading\">Technician<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/teo-fernez\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/teo-fernez\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/fernez_teo_crcm.jpg\" alt=\"Fernez T&#xE9;o - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">T\u00e9o Fernez<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/theo-wirth\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/theo-wirth\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/wirth_theo_crcm.jpg\" alt=\"Wirth Th&#xE9;o - Centre de recherche en canc&#xE9;rologie de Marseille - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Th\u00e9o Wirth<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=3291\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yara-rym-el-hawly\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Yara-rym-el-Hawly_crcm.jpg\" alt=\"Yara Rym El-Hawly\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yara Rym El-Hawly<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/amira-ben-amara\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/amira-ben-amara\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/ben_amara_amira_crcm.jpg\" alt=\"Ben amara Ben Hadid Amira - Immunity and Cancer Team - CRCM - Immunomonitoring Platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Amira Ben Amara<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/diane-rattier\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/diane-rattier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/rattier_diane_crcm.jpg\" alt=\"Rattier Diane - Marseille Cancer Research Center - Immunomonitoring platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Diane Rattier<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/emilien-billon\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/emilien-billon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Emilien-Billon.jpg\" alt=\"Emilien Billon\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Emilien Billon<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral Hospital Practitioner<\/h4>\n\n<p>The Immunomonitoring in Cancer (PIC) platform, located on the campus of the Institut Paoli-Calmettes, is part of the Marseille Cancer Research Center and is affiliated with the IPC, Inserm, CNRS and Aix-Marseille University. IBiSA-certified since 2008 and ISO 9001 (2015) and NF X50-900 (2016) certified, the platform is open to the academic and industrial scientific community as part of collaborations and\/or project services related to oncology and immunology. <\/p>\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\">Skills and expertise<\/h3>\n\n<p>&#8211; Analysis of the tumor microenvironment as part of basic and preclinical research projects in experimental models and in humans<\/p>\n\n<p>&#8211; Identifying the mechanisms involved in the development of cancer-related alterations in innate and adaptive immunity<\/p>\n\n<p>&#8211; Preclinical development of biotherapies<\/p>\n\n<p>&#8211; Development and validation of biomarkers (diagnostic, prognostic and predictive of response and toxicity) in hemopathies and solid tumors treated with immunotherapy<\/p>\n\n<p>&#8211; Monitoring anti-tumor responses to immunotherapy (monoclonal antibodies, vaccination, transplantation):<br\/>&gt; Mapping immune populations and therapeutic targets<br\/>&gt; Monitoring the binding of therapeutic antibodies to immune populations<\/p>\n\n<p>&gt; Monitoring of cellular status following therapeutic antibody binding<\/p>\n\n<p>&gt; Identification of alternative checkpoints for immunotherapy combinations<\/p>\n\n<p>&gt; Study of immunotherapy resistance mechanisms<\/p>\n\n<h3 class=\"wp-block-heading\">Activities<\/h3>\n\n<p>&#8211; Handling of patient samples (blood, marrow and tissue)<br\/>&#8211; Assay of cytokines, chemokines and soluble biomarkers (ELISA, Luminex)<br\/>&#8211; RNA and\/or DNA assay, RNA and\/or DNA extraction<br\/>&#8211; Reverse transcription and RQ-PCR<br\/>&#8211; Genotyping<br\/>&#8211; Plasmid production<br\/>&#8211; Single or double expansion of NK lymphocytes and Tgd lymphocytes<br\/>&#8211; 3D culture (spheroids, organoids)<br\/>&#8211; Immunofluorescence (IF) and RNAscope<br\/>&#8211; Phenotyping in multiparametric cytometry (conventional cytometry, spectral cytometry and mass cytometry) to characterize cell populations<br\/>&#8211; In vitro functional assays (cytotoxicity, proliferation, cytokine production)<br\/>&#8211; Transcriptomics, scRNAseq<br\/>&#8211; Statistical analysis (correlation between biological and clinical parameters)<br\/>&#8211; Bioinformatics analysis of high-dimensional data (machine learning)<\/p>\n\n<h3 class=\"wp-block-heading\">Equipment<\/h3>\n\n<p>&#8211; Culture room (P1, P2) with microbiological safety station (PSM)<br\/>&#8211; CO2 incubator for cell culture (Heraeus)<br\/>&#8211; Centrifuges (Thermoscientific)<br\/>&#8211; Inverted microscopes (Olympus)<br\/>&#8211; Flow cytometer: canto II (BD Biosciences)<br\/>&#8211; Mass cytometer : Helios (Standard Biotools)<br\/>&#8211; Luminex Bio-Plex 200 (Bio-Rad)<br\/>&#8211; Bioanalyzer (Agilent)<br\/>&#8211; Hybridization oven (Bio-Techne)<br\/>&#8211; Spectro-fluo-photometer (proteigene)<br\/>&#8211; Various small items of equipment: gentleMACS Dissociator (Miltenyi), laboratory balance, &#8230;<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-left-crcm.png\" alt=\"Form orange platform publications Marseille Cancer Research Center\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-right-crcm.png\" alt=\"Form orange platform publications Marseille Cancer Research Center\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>09\/2023<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37379438\/\" target=\"_blank\" rel=\"noreferrer noopener\">CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer.<\/a><\/strong><\/p>\n\n<p>S Fattori, A Le Roy, J Houacine, L Robert, R Abes, L Gorvel, S Granjeaud, MS Rouvi\u00e8re, A Ben Amara, N Boucherit, C Tarpin, J Pakradouni, E Charafe-Jauffret, G Houvenaeghel, E Lambaudie, F Bertucci, P Rochigneux, A Gon\u00e7alves, A Foussat, AS Chretien, D Olive. <em>Cancer Research 2023<\/em><em>.<\/em><\/p>\n\n<p>05\/2023<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37230538\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors.<\/a><\/strong><\/p>\n\n<p>Demerl\u00e9 C, Gorvel L, Mello M, Pastor S, Degos C, Zarubica A, Angelis F, Fiore F, Nunes JA, Malissen B, Greillier L, Guittard G, Luche H, Barlesi F, Olive D.  <em>J Immunother Cancer. 2023.<\/em><\/p>\n\n<p>12\/2022<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36166003\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mass cytometry reveals classical monocytes, NK cells and ICOS+ CD4+ T cells associated with pembrolizumab efficacy in lung cancer patients.<\/a><\/strong><\/p>\n\n<p>P Rochigneux, A Lisberg, A Garcia, S Granjeaud, A Madroszyk, S Fattori, A Gon\u00e7alves, R Devillier, P Maby, N Salem, L Gorvel, B Chanez, J Gukasyan, J Caroll, J Goldman, AS Chretien, D Olive, E Garon.  <em>Clinical Cancer Research 2022.<\/em><\/p>\n\n<p>01\/2023<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36459926\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tumor associated macrophage in HPV+ tumors: Between immunosuppression and inflammation.<\/a><\/strong><\/p>\n\n<p>Gorvel L, Olive D.  <em>Semin Immunol. 2023<\/em>.<\/p>\n\n<p>06\/2021<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34050021\/\" target=\"_blank\" rel=\"noreferrer noopener\">High-dimensional mass cytometry analysis of NK cell alterations in Acute Myeloid Leukemia identifies a subgroup with adverse clinical outcome.<\/a><\/strong><\/p>\n\n<p>AS Chretien, R Devillier, S Granjeaud, C Cordier, C Demerle, N Salem, J Wlosik, F Orlanducci, E Gregori, M Paul, P Rochigneux, T Pagliardini, M Morey, C Fauriat, N Dulphy, A Toubert, H Luche, M Malissen, D Blaise, J Nun\u00e8s, N Vey, D Olive.  <em>PNAS 2021.<\/em><\/p>\n\n<p>10\/2020<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34669444\/\" target=\"_blank\" rel=\"noreferrer noopener\">Development of ICT01, a first-in-class, anti-BTN3A antibody for activating V\u03b39V\u03b42 T cell-mediated antitumor immune response.<\/a><\/strong><\/p>\n\n<p>De Gassart A, Le KS, Brune P, Agaugu\u00e9 S, Sims J, Goubard A, Castellano R, Joalland N, Scotet E, Collette Y, Valentin E, Ghigo C, Pasero C, Colazet M, Guill\u00e9n J, Cano CE, Marabelle A, De Bonno J, Hoet R, Truneh A, Olive D, Frohna P.  <em>Sci Transl Med. 2021.<\/em><\/p>\n\n<p>12\/2020<\/p>\n\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33362787\/\" target=\"_blank\" rel=\"noreferrer noopener\">3D Tumor Models and Their Use for the Testing of Immunotherapies.<\/a><\/strong><\/p>\n\n<p>Boucherit N, Gorvel L, Olive D.  <em>Front Immunol. 2020.<\/em><\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%28CHRETIEN+AS%5BAuthor%5D%29+OR+%28OLIVE+D%5BAuthor%5D%29%29+AND+%28CRCM%5BAffiliation%5D+OR+Centre+de+Recherche+en+Canc%C3%A9rologie+de+Marseille%5BAffiliation%5D+OR+Cancer+Research+Center+of+Marseille%5BAffiliation%5D%29&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.sfdermato.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><a href=\"https:\/\/www.laurettefugain.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ibisa.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.frm.org\/fr\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/canceropole-paca.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.fondationdefrance.org\/fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sfdermato.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><a href=\"https:\/\/www.laurettefugain.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ibisa.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.frm.org\/fr\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/canceropole-paca.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.fondationdefrance.org\/fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sfdermato.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><a href=\"https:\/\/www.laurettefugain.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ibisa.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/salem_nassim_crcm.jpg\" alt=\"Salem Nassim - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Nassim Salem<\/h5>\n\n<h5 class=\"wp-block-heading\">PhramD, PhD<br\/>Post-doctoral fellow in Dr Mohamad Hamieh&#8217;s team,<br\/>Weil Cornell Medicine<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/barabarat_bernadette_crcm.jpg\" alt=\"Barabarat Bernadette - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Bernadette Barabarat<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<br\/>IPC Senior Technician<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/just_sylvaine_crcm.jpg\" alt=\"just Sylvaine - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Sylvaine Just<\/h5>\n\n<h5 class=\"wp-block-heading\">IPC qualified technician<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/morel_yannis_crcm.jpg\" alt=\"Morel Yannis - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Yannis Morel<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD, Executive Vice President,<br\/>product strategy &amp; business development and member<br\/>of Innate Pharma&#8217;s Management Board<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/chambost_herve_crcm.jpg\" alt=\"Chambost herv&#xE9; - Marseille cancer research center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Herv\u00e9 Chambost<\/h5>\n\n<h5 class=\"wp-block-heading\">M.D, PhD<br\/>PU-PH at Timone Children&#8217;s Hospital,<br\/>Marseille Hemophilia Reference Center<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/costello_regis_crcm.jpg\" alt=\"Costello R&#xE9;gis - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">R\u00e9gis Costello<\/h5>\n\n<h5 class=\"wp-block-heading\">M.D, PhD<br\/>PU-PH in the Hematology and Cell Therapy Department,<br\/>Marseille<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/immunomonitoring-platform\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a> &amp; <a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immunomonitoring Paoli Calmettes Institute Anne-Sophie Chr\u00e9tien Platform Manager Daniel Olive Platform Manager T\u00e9o Fernez<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5925,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5943","page","type-page","status-publish","hentry"],"yoast_head":"<!-- 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