{"id":5941,"date":"2025-01-02T09:31:50","date_gmt":"2025-01-02T08:31:50","guid":{"rendered":"https:\/\/crcm-marseille.fr\/our-technology-platforms\/platform-for-imaging-and-characterization-of-dna-damage-and-abnormalities-pic-dna\/"},"modified":"2025-11-18T10:35:38","modified_gmt":"2025-11-18T09:35:38","slug":"pic-adn","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/","title":{"rendered":"PIC-ADN"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"logo-crcm\"\/><\/a><\/figure>\n\n\n\n<ul id=\"menu-main-menu\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a>Our center<\/a><\/li>\n\n\n\n<li><a>Our research<\/a><\/li>\n\n\n\n<li><a>For students<\/a><\/li>\n\n\n\n<li><a>For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/our-research-teams\/\">The research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/#\"><\/a><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/plugins\/sitepress-multilingual-cms\/res\/flags\/en.svg\" alt=\"English\"\/><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\">PIC-ADN<\/h1>\n\n\n\n<p>Paoli Calmettes Institute<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\" mfn-coverimg-wrapper\" href=\"https:\/\/crcm-marseille.fr\/team\/magda-rodrigues\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"\"\/><\/a><\/figure>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/magda-rodrigues\/\">Magda Rodrigues<\/a><\/p>\n\n\n\n<p>Platform manager<\/p>\n\n\n\n<p>The Plateform d&#8217;Imagerie et de Caract\u00e9risation des Anomalies et Dommages dans l&#8217;ADN (PIC-ADN)&nbsp;offers a technical platform for photonic microscopy, including wide-field, confocal and structured light microscopy ( ), and a service for the study of genomic instability. It provides equipment for the analysis of samples, whether fixed or observed dynamically. Open to CRCM teams and private partners, it also offers training services, consultancy and assistance in image processing.<\/p>\n\n\n\n<p>The Platform for Imaging and Characterization of DNA Damage and Abnormalities is essentially organized around photonic microscopy techniques: wide-field, confocal and structured light microscopy&#8230;<br>It offers a coherent set of equipment that enables work to be carried out using different exploration methods: either on cells or tissue fragments fixed on fluorescent or stained samples, or on samples studied dynamically, whether using fluorescence or phase contrast techniques.<br>This platform is shared by all CRCM teams and open to private partners. It offers training, consultancy, interpretation support, image processing and analysis, technology watch, management and organization services. It also offers a range of services for the study of genomic instability, from sample preparation and image acquisition to data analysis and figure shaping.<\/p>\n\n\n\n<p>The platform is managed and coordinated by a design engineer and includes the following equipment:<\/p>\n\n\n\n<p>&gt; A Zeiss LSM 880 confocal microscope equipped with the Airyscan enhancement module.<br>&gt; A NIKON AX Confocal microscope equipped with a UVA (365nm) FRAP module.<br>&gt; A multi-point confocal microscope equipped with a spinning disk, FRAP, FLIP, photo-activation and TIRF capability.<br>&gt; An Apotome-type structured-light fluorescence microscope (Zeiss) equipped with a color camera for colored samples.<br>&gt; Two time-lapse fluorescence microscopes (Zeiss-Roper Scientifics and Olympus).<br>&gt; A fluorescence microscope equipped for molecular combing.<br>&gt; A Genomic Vision fluorescence slide scanner.<br>&gt; Computerized image processing and analysis stations.<\/p>\n\n\n\n<p>The platform is constantly evolving to keep pace with project realities and user needs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Equipment<\/h3>\n\n\n\n<p>Confocal LSM 880 + Airyscan<\/p>\n\n\n\n<p>Confocal AX NIKON + FRAP UV<\/p>\n\n\n\n<p>Confocal Spinning-Disk ZEISS<\/p>\n\n\n\n<p>APOTOME ZEISS microscope<\/p>\n\n\n\n<p>ZEISS Videomicroscope<\/p>\n\n\n\n<p>Olympus Videomicroscope<\/p>\n\n\n\n<p>Fluorescence slide scanner<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-left-crcm.png\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-right-crcm.png\" alt=\"\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n\n\n<p>08\/2023<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad559\" target=\"_blank\" rel=\"noreferrer noopener\">A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells. Nucleic Acids Research, 51(15), 7988-8004.<\/a><\/p>\n\n\n\n<p>Berrada, S., Mart\u00ednez-Balsalobre, E., Larcher, L., Azzoni, V., Vasquez, N., Da Costa, M., Abel, S., Audoly, G., Lee, L., Montersino, C., Castellano, R., Combes, S., Gelot, C., Ceccaldi, R., Guervilly, J., Soulier, J., &amp; Lachaud, C.<\/p>\n\n\n\n<p>09\/2021<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1126\/sciadv.abc7371\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science Advances, 7(39).<\/strong><\/a><\/p>\n\n\n\n<p>Lee, L., Oliva, A. B. P., Martinez-Balsalobre, E., Churikov, D., Peter, J., Rahmouni, D., Audoly, G., Azzoni, V., Audebert, S., Camoin, L., Mulero, V., Cayuela, M., Kulathu, Y., Geli, V., &amp; Lachaud, C.<\/p>\n\n\n\n<p>09\/2023<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1073\/pnas.2310914120\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>PDZ scaffolds regulate extracellular vesicle production, composition, and uptake. Proceedings of the National Academy of Sciences, 120(38).<\/strong><\/a><\/p>\n\n\n\n<p>Castro-Cruz, M., Hyka, L., Daaboul, G., Leblanc, R., Meeussen, S., Lembo, F., Oris, A., Van Herck, L., Granjeaud, S., David, G., &amp; Zimmermann, P.<\/p>\n\n\n\n<p>03\/2024<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1073\/pnas.2312820121\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveri. Proceedings of the National Academy of Sciences, 121(12).<\/strong><\/a><\/p>\n\n\n\n<p>Legrand, S., Saifudeen, A., Bordelet, H., Vernerey, J., Guille, A., Bignaud, A., Thierry, A., Acquaviva, L., Gaudin, M., Sanchez, A., Johnson, D., Friedrich, A., Schacherer, J., Neale, M. J., Borde, V., Koszul, R., &amp; Llorente, B.<\/p>\n\n\n\n<p>09\/2024<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1101\/gad.352032.124\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders. Genes &amp; Development.<\/strong><\/a><\/p>\n\n\n\n<p>Kochman, R., Ba, I., Yates, M., Pirabakaran, V., Gourmelon, F., Churikov, D., Lafaille, M., Kermasson, L., Hamelin, C., Marois, I., Jourquin, F., Braud, L., Bechara, M., Lainey, E., Nunes, H., Breton, P., Penhouet, M., David, P., G\u00e9li, V., &amp; Coulon, S.<\/p>\n\n\n\n<p>10\/2023<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.15252\/emmm.202317570\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Downregulation of stromal syntenin sustains AML development. EMBO Molecular Medicine, 15(11).<\/strong><\/a><\/p>\n\n\n\n<p>Leblanc, R., Ghossoub, R., Goubard, A., Castellano, R., Fares, J., Camoin, L., Audebert, S., Balzano, M., Bou-Tayeh, B., Fauriat, C., Vey, N., Garciaz, S., Borg, J., Collette, Y., Aurrand-Lions, M., David, G., &amp; Zimmermann, P.<\/p>\n\n\n\n<p>02\/2024<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s44319-023-00041-1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema. EMBO Reports, 25(3), 1650-1684<\/strong><\/a><\/p>\n\n\n\n<p>Lipskaia, L., Breau, M., Cayrou, C., Churikov, D., Braud, L., Jacquet, J., Born, E., Fouillade, C., Curras-Alonso, S., Bauwens, S., Jourquin, F., Fiore, F., Castellano, R., Josselin, E., S\u00e1nchez-Ferrer, C., Giovinazzo, G., Lachaud, C., Gilson, E., Flores, I., &amp; G\u00e9li, V.<\/p>\n\n\n\n<p>04\/2022<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acschembio.1c00826\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Discovery of Small-Molecule Inhibitors of the PTK7\/\u03b2-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chemical Biology, 17(5), 1061-1072.<\/strong><\/a><\/p>\n\n\n\n<p>Ganier, L., Betzi, S., Derviaux, C., Roche, P., Dessaux, C., Muller, C., Hoffer, L., Morelli, X., &amp; Borg, J.<\/p>\n\n\n\n<p>04\/2024<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.jbc.2024.106792\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A vertebrate Vangl2 translational variant required for planar cell polarity. Journal of Biological Chemistry, 300(4), 106792.<\/strong><\/a><\/p>\n\n\n\n<p>Walton, A., Thom\u00e9, V., Revinski, D., Marchetto, S., Puvirajesinghe, T. M., Audebert, S., Camoin, L., Bailly, E., Kodjabachian, L., &amp; Borg, J.<\/p>\n\n\n\n<p>09\/2022<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1242\/jcs.259347\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>The serine\/threonine kinase MINK1 directly regulates the function of promigratory proteins. Journal of Cell Science, 135(17).<\/strong><\/a><\/p>\n\n\n\n<p>Daulat, A. M., Wagner, M. S., Audebert, S., Kowalczewska, M., Ariey-Bonnet, J., Finetti, P., Bertucci, F., Camoin, L., &amp; Borg, J.<\/p>\n\n\n\n<p>02\/2021<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41598-021-81697-4\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Syntenin-knock out reduces exosome turnover and viral transduction. Scientific Reports, 11(1).<\/strong><\/a><\/p>\n\n\n\n<p>Kashyap, R., Balzano, M., Lechat, B., Lambaerts, K., Egea-Jimenez, A. L., Lembo, F., Fares, J., Meeussen, S., K\u00fcgler, S., Roebroek, A., David, G., &amp; Zimmermann, P.<\/p>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/#\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/intra-crcm.marseille.inserm.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Intranet connection<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/annuaire\/\">Directory<\/a><br><a href=\"https:\/\/www.institutpaolicalmettes.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">IPC collaboration<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/actualites\/\">News<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/en\/our-center\/partnerships-and-innovation\/\">Partnerships &amp; Innovation<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/en\/terms-of-use\/\">Terms &amp; Conditions<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/politique-de-confidentialite\/\">Privacy policy<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br>13273 Marseille Cedex 09<\/p>\n\n\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/contact\/\">Contact us<br>How to get here<\/a><\/p>\n\n\n\n<p>Follow us<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/\"><\/a><\/p>\n\n\n\n<p>www.crcm-marseille.fr \u00a92024 | Tous droits r\u00e9serv\u00e9s &#8211; R\u00e9alis\u00e9 par&nbsp;<a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a>&nbsp;&amp;&nbsp;<a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/#\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/plugins\/sitepress-multilingual-cms\/res\/flags\/en.svg\" alt=\"English\"\/><\/figure>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/pic-adn\/#\"><\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PIC-ADN Paoli Calmettes Institute Magda Rodrigues Platform manager The Plateform d&#8217;Imagerie et de Caract\u00e9risation<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5925,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5941","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - 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