{"id":5939,"date":"2025-01-06T14:21:26","date_gmt":"2025-01-06T13:21:26","guid":{"rendered":"https:\/\/crcm-marseille.fr\/our-technology-platforms\/hits-platform-high-throughput-screening-platform\/"},"modified":"2025-11-18T10:29:13","modified_gmt":"2025-11-18T09:29:13","slug":"hits","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/hits\/","title":{"rendered":"HiTS"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"logo-crcm\"\/><\/a><\/figure>\n\n\n\n<ul id=\"menu-main-menu\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a>Our center<\/a><\/li>\n\n\n\n<li><a>Our research<\/a><\/li>\n\n\n\n<li><a>For students<\/a><\/li>\n\n\n\n<li><a>For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/our-research-teams\/\">The research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/hits\/#\"><\/a><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/plugins\/sitepress-multilingual-cms\/res\/flags\/en.svg\" alt=\"English\"\/><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\">HiTS &#8211; High-throughput screening platform<\/h1>\n\n\n\n<p>Paoli Calmettes Institute<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\" mfn-coverimg-wrapper\" href=\"https:\/\/crcm-marseille.fr\/team\/xavier-morelli\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/morelli_xavier_crcm.jpg\" alt=\"\"\/><\/a><\/figure>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/xavier-morelli\/\">Xavier Morelli<\/a><\/p>\n\n\n\n<p>scientific manager<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\" mfn-coverimg-wrapper\" href=\"https:\/\/crcm-marseille.fr\/team\/Carine-Derviaux\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/derviaux_carine_crcm.jpg\" alt=\"\"\/><\/a><\/figure>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/carine-derviaux\/\">Carine Derviaux<\/a><\/p>\n\n\n\n<p>Technical Manager<\/p>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/sara-scaramuzzino\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/sara-scaramuzzino\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/scaramuzzino_sara_crcm.jpg\" alt=\"Scaramuzzino Sara - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Sara Scaramuzzino<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieure<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/stephane-betzi\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/stephane-betzi\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/betzi_stephane_crcm.jpg\" alt=\"Betzi St\u00e9phane - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM - Plateforme HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">St\u00e9phane Betzi<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/thomas-miller\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/thomas-miller\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/miller_thomas_crcm.jpg\" alt=\"Miller Thomas projet Petites Molecules en Immunotherapie \u00e9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - Centre de Recherche en Canc\u00e9rologie de Marseille - HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Thomas Miller<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/eddy_pasquier_plateforme_hits_crcm.jpg\" alt=\"Eddy Pasquier\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Eddy Pasquier<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur \/ Responsable d&#8217;\u00e9quipe<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/muller_kevin_crcm.jpg\" alt=\"Kevin Muller - \u00c9quipe Pharmacologie Mol\u00e9culaire invers\u00e9e en oncologie p\u00e9diatrique (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Kevin Muller<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/magali-saez-ayala\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/magali-saez-ayala\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/saez_ayala_magali_crcm.jpg\" alt=\"Saez Ayla Magali - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Magali Saez Ayala<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieure<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-jeanne-basse\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/marie-jeanne-basse\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/basse_marie_jeanne_crcm.jpg\" alt=\"Base Marie-Jeanne - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - Plateforme HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Marie-Jeanne Basse<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Assistante-Ing\u00e9nieure<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mary-ann-steadman\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/mary-ann-steadman\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/Mary-Ann-Steadman.jpg\" alt=\"Mary-Ann Steadman\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Mary-Ann Steadman<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieure<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/philippe-roche\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/philippe-roche\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/roche_philippe_crcm.jpg\" alt=\"Roche Philippe - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM - Plateforme HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Philippe Roche<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/sara-scaramuzzino\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/sara-scaramuzzino\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/scaramuzzino_sara_crcm.jpg\" alt=\"Scaramuzzino Sara - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Sara Scaramuzzino<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieure<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/stephane-betzi\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/stephane-betzi\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/betzi_stephane_crcm.jpg\" alt=\"Betzi St\u00e9phane - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM - Plateforme HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">St\u00e9phane Betzi<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/thomas-miller\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/thomas-miller\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/miller_thomas_crcm.jpg\" alt=\"Miller Thomas projet Petites Molecules en Immunotherapie \u00e9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - Centre de Recherche en Canc\u00e9rologie de Marseille - HiTS \u2013 Plateforme de criblage \u00e0 haut d\u00e9bit\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Thomas Miller<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/eddy_pasquier_plateforme_hits_crcm.jpg\" alt=\"Eddy Pasquier\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Eddy Pasquier<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Chercheur \/ Responsable d&#8217;\u00e9quipe<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/muller_kevin_crcm.jpg\" alt=\"Kevin Muller - \u00c9quipe Pharmacologie Mol\u00e9culaire invers\u00e9e en oncologie p\u00e9diatrique (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Kevin Muller<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieur<\/h4>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/magali-saez-ayala\/\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a class=\"sptp-member-avatar \" href=\"https:\/\/crcm-marseille.fr\/team\/magali-saez-ayala\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/saez_ayala_magali_crcm.jpg\" alt=\"Saez Ayla Magali - \u00c9quipe Biologie Structurale et Chimie-Biologie Int\u00e9gr\u00e9e - CRCM\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Magali Saez Ayala<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Ing\u00e9nieure<\/h4>\n\n\n\n<p>The HiTS platform brings together a range of skills and technologies&nbsp;to accelerate the discovery of bioactive molecules, whether through experimental screening in vitro or in cellulo, or through molecular modeling approaches for drug design. Our objectives are to identify, understand, validate and target signaling pathways involving key targets of tumor development (enzymes, protein\/protein interaction surfaces&#8230;) with the specific aim of facilitating the transfer of identified therapeutic \/ pharmacological targets to preclinical and clinical development programs in oncology. The platform is open to the scientific community and can support your research projects on a collaborative or service basis.<\/p>\n\n\n\n<p><strong>HiTS high throughput screening<\/strong><\/p>\n\n\n\n<p>The platform&nbsp;<strong>provides its collaborators with a robotized high-throughput screening facility<\/strong>&nbsp;comprising the echo650 acoustic distributor for very low volumes, a robotic centrifuge, an automatic plate sealer, and a high-performance multi-purpose reader (fluorescence, absorbance, luminescence). It also boasts a versatile high-volume dispensing robot. This range of equipment ensures that the robotization unit remains operational, enabling experiments to be carried out quickly and reliably.<\/p>\n\n\n\n<p>This unique high-tech service provides the tools needed to meet the scientific challenges encountered in the early development of innovative oncology products.<\/p>\n\n\n\n<p><strong>Molecular modeling for drug design<\/strong><\/p>\n\n\n\n<p>The particularity of this platform is to integrate on the same site not only HTS screening know-how, but also chemoinformatics\/molecular modeling through the platform managed by Philippe Roche (INT-3D platform), which is now integrated into HiTS. We can therefore offer a range of services incorporating not only chemical library management but also post-screening sub-family selection, enabling users to consider catalogue-based SAR studies at lower cost, and also, once hits have been validated and IC50s measured after powder repurchase, to start &#8216;hit to lead&#8217; phases within the same platform.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Know-how \/ Technologies<\/h3>\n\n\n\n<p>&#8211;&nbsp;Expression&nbsp;, production and purification of recombinant proteins<br>&#8211; Assay&nbsp;development&nbsp;for protein-protein or protein-ligand interaction studies (TR-FRET, HTRF, Fluorescence, TSA, enzymatic assays)<br>&#8211;&nbsp;Miniaturization&nbsp;and robotization of assays in 384\/1536-well plates<br>&#8211; High-throughput&nbsp;<em>in vitro<\/em>&nbsp;screening&nbsp;using acoustic technology<br>&#8211; High-throughput&nbsp;<em>in-cell<\/em>&nbsp;pharmacological&nbsp;screening&nbsp;using 2D and 3D cytotoxicity measurements, in monotherapy and combination, by luminescence, fluorescence and absorbance (Cell Titer Glo, Alamar Blue, Luciferase, Caspase Glo&#8230;).<br>&#8211; Biophysical&nbsp;validation&nbsp;of keys (TSA, ITC, X-Ray)<br>&#8211; Chemoinformatics&nbsp;study&nbsp;of key molecules<br>&#8211;&nbsp;Structure-Activity&nbsp;Relationship (SAR) by catalog<br>&#8211; Molecular&nbsp;modeling&nbsp;\/ Molecular dynamics \/ Virtual screening<br>&#8211; Hit-to-lead&nbsp;optimization&nbsp;(ChemoDOTS)<br>&#8211;&nbsp;Development of&nbsp;covalent probes (CovaDOTS &#8211; CovaLink &#8211; CovaGrow &#8211; CovaProbe)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Resources<\/h3>\n\n\n\n<h5 class=\"wp-block-heading\">equipment<\/h5>\n\n\n\n<p>&#8211; ACCESS&nbsp;platform&nbsp;with robotic arm (Beckman)<br>&#8211; Echo650 acoustic&nbsp;transfer&nbsp;(Beckman)<br>&#8211; Versatile&nbsp;distribution&nbsp;Certus Flex (Fritz Gyger)<br>&#8211; Pherastar FS Fluorescence, Absorbance, Luminescence microplate&nbsp;reader&nbsp;(BMG Labtech)<br>&#8211;&nbsp;RT-PCR&nbsp;384-well CFX384 (Biorad)<br>&#8211;&nbsp;FPLC&nbsp;Akta Pure (Cytivia)<br>&#8211;&nbsp;Microcalorimeter&nbsp;ITC200 (Malvern)<br>&#8211;&nbsp;Incubators&nbsp;(Cell culture\/Xray)<br>&#8211; ShortDundee&nbsp;pods&nbsp;(Roylan Developments) for storing chemical libraries under nitrogen.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Chemical libraries<\/h5>\n\n\n\n<p>&#8211;&nbsp;<strong>Protein-proteininteraction&nbsp;<\/strong>: Fr-PPIChem 10,314<br>&#8211;<strong>Repositioning&nbsp;<\/strong>: Prestwick 1,520<br>&#8211;<strong>Fragments&nbsp;<\/strong>: Fragments 1,000<br>&#8211;<strong>Crossing the blood-brain barrier&nbsp;<\/strong>: HITCH 110<br>&#8211;<strong>Metabolism&nbsp;<\/strong>: METABO 148<br>&#8211;<strong>Leukemia&nbsp;<\/strong>: TrGET 42<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Database \/ Servers \/ Software<\/h5>\n\n\n\n<p>&#8211;&nbsp;<strong>2P2IDB&nbsp;<\/strong>: protein-protein interaction modulators<br>&#8211;&nbsp;<strong>Fr-PPIChemDB&nbsp;<\/strong>: experimental screening<br>&#8211;&nbsp;<strong>iscbmolDB&nbsp;<\/strong>: Molecules<br>&#8211;&nbsp;<strong>ChemoDOTS&nbsp;<\/strong>: Hit2Lead optimization<br>&#8211;&nbsp;<strong>Software used&nbsp;<\/strong>: Modeller &#8211; VMD &#8211; PyMOL &#8211; Charmm &#8211; Amber &#8211; NAMD &#8211; ChemAxon &#8211; SeeSAR &#8211; LigandScout &#8211; RDKit &#8211; MOE &#8211; PLANTS &#8211; DataWarrior &#8211; Alphafold &#8211; Schrodinger Life Science Suite<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Teaching<\/h3>\n\n\n\n<p>In silico Drug Design<\/p>\n\n\n\n<p>Experimental screening<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n\n\n\n<li><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-left-crcm.png\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/forme-orange-plateforme-right-crcm.png\" alt=\"\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n\n\n<p>04\/2024<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae326\" target=\"_blank\" rel=\"noreferrer noopener\">ChemoDOTS: a web server to design chemistry-driven focused libraries.<\/a><\/strong><\/p>\n\n\n\n<p>Hoffer L, Charifi-Hoareau G, Barelier S, Betzi S, Miller T, Morelli X, Roche P.<\/p>\n\n\n\n<p>05\/2023<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-38668-2\" target=\"_blank\" rel=\"noreferrer noopener\">From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia. Nat Commun.<\/a><\/strong><\/p>\n\n\n\n<p>Saez-Ayala M, Hoffer L, Abel S, Ben Yaala K, Sicard B, Andrieu GP, Latiri M, Davison EK, Ciufolini MA, Br\u00e9mond P, Rebuffet E, Roche P, Derviaux C, Voisset E, Montersino C, Castellano R, Collette Y, Asnafi V, Betzi S, Dubreuil P, Combes S, Morelli X.<\/p>\n\n\n\n<p>09\/2023<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104752\" target=\"_blank\" rel=\"noreferrer noopener\">Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms. EBioMedicine.<\/a><\/strong><\/p>\n\n\n\n<p>Ariey-Bonnet J, Berges R, Montero MP, Mouysset B, Piris P, Muller K, Pinna G, Failes TW, Arndt GM, Morando P, Baeza-Kallee N, Colin C, Chinot O, Braguer D, Morelli X, Andr\u00e9 N, Carr\u00e9 M, Tabouret E, Figarella-Branger D, Le Grand M, Pasquier E.<\/p>\n\n\n\n<p>04\/2022<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/doi.org\/10.1021\/acschembio.1c00826\" target=\"_blank\" rel=\"noreferrer noopener\">Discovery of Small-Molecule Inhibitors of the PTK7\/\u03b2-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.<\/a><\/strong><\/p>\n\n\n\n<p>Ganier L, Betzi S, Derviaux C, Roche P, Dessaux C, Muller C, Hoffer L, Morelli X, Borg JP.<\/p>\n\n\n\n<p>03\/2020<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jmedchem.9b02000\" target=\"_blank\" rel=\"noreferrer noopener\">Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents.<\/a><\/strong><\/p>\n\n\n\n<p>Ana C. Carrasco, Vanessa Rodr\u00edguez-Fanjul, Abraha Habtemariam, and Ana M. Pizarro<\/p>\n\n\n\n<p>04\/2020<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/doi.org\/10.1021\/acschembio.0c00179\" target=\"_blank\" rel=\"noreferrer noopener\">Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions.<\/a><\/strong><\/p>\n\n\n\n<p>Bosc N, Muller C, Hoffer L, Lagorce D, Bourg S, Derviaux C, Gourdel ME, Rain JC, Miller TW, Villoutreix BO, Miteva MA, Bonnet P, Morelli X, Sperandio O, Roche P.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ibisa.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/fr\/public\/les-plateformes-technologiques\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/chembiofrance.cn.cnrs.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/intra-crcm.marseille.inserm.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Intranet connection<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/annuaire\/\">Directory<\/a><br><a href=\"https:\/\/www.institutpaolicalmettes.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">IPC collaboration<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/actualites\/\">News<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/en\/our-center\/partnerships-and-innovation\/\">Partnerships &amp; Innovation<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/en\/terms-of-use\/\">Terms &amp; Conditions<\/a><br><a href=\"https:\/\/crcm-marseille.fr\/politique-de-confidentialite\/\">Privacy policy<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br>13273 Marseille Cedex 09<\/p>\n\n\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/contact\/\">Contact us<br>How to get here<\/a><\/p>\n\n\n\n<p>Follow us<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/hits\/\"><\/a><\/p>\n\n\n\n<p>www.crcm-marseille.fr \u00a92024 | Tous droits r\u00e9serv\u00e9s &#8211; R\u00e9alis\u00e9 par&nbsp;<a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a>&nbsp;&amp;&nbsp;<a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/hits\/#\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/plugins\/sitepress-multilingual-cms\/res\/flags\/en.svg\" alt=\"English\"\/><\/figure>\n\n\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/our-technology-platforms\/hits\/#\"><\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HiTS &#8211; High-throughput screening platform Paoli Calmettes Institute Xavier Morelli scientific manager Carine Derviaux<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5925,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5939","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - 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