{"id":5916,"date":"2024-11-27T12:40:39","date_gmt":"2024-11-27T11:40:39","guid":{"rendered":"https:\/\/crcm-marseille.fr\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/"},"modified":"2025-11-18T10:07:20","modified_gmt":"2025-11-18T09:07:20","slug":"reverse-molecular-pharmacology-in-pediatric-oncology-remap-4-kids","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-remap-4-kids\/","title":{"rendered":"Reverse Molecular Pharmacology in Pediatric Oncology (REMAP-4kids)"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-translate-it-crcm-1-1024x622.png\" alt=\"Translate-it department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">Reverse molecular pharmacology in pediatric oncology (REMAP-4kids)<\/h1>\n\n<p>Institut Paoli Calmettes &amp; Facult\u00e9 de Pharmacie de la Timone<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/x.com\/eddpasquier\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/pasquier_eddy_crcm.jpg?ver=1737475119\" alt=\"Eddy Pasquier - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/eddy-pasquier\/\">Eddy Pasquier<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/nicolas-andre\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/Nicolas_ANDRE-300.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/nicolas-andre\/\">Nicolas Andr\u00e9<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mohammed-taha\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mohammed-taha\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/taha_mohammed_crcm.jpg\" alt=\"Taha Mohammed - Reverse Molecular Pharmacology in Pediatric Oncology team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mohammed Taha<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/patricia-piris\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/patricia-piris\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Patricia Piris\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Patricia Piris<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-bourgarel\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-bourgarel\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Veronique-BOURGAREL-crcm.jpg\" alt=\"V&#xE9;ronique Bourgarel\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">V\u00e9ronique Bourgarel<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/arnauld-verschuur\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/arnauld-verschuur\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Arnaud-Verschuur-crcm.jpg\" alt=\"Arnauld Verschuur\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Arnauld Verschuur<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christine-roux\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christine-roux\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/roux_christine_crcm.jpg\" alt=\"Christine Roux - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Christine Roux<\/h2>\n\n<h4 class=\"wp-block-heading\">Assistant Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/florent-sauteret\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/florent-sauteret\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Florent-SAUTERET-crcm.jpg\" alt=\"Florent Sauteret\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Florent Sauteret<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/gabriel-revon-riviere\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/gabriel-revon-riviere\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Gabriel-Revon-Riviere-crcm.jpg\" alt=\"Gabriel Revon Rivi&#xE8;re\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Gabriel Revon Rivi\u00e8re<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/julie-lafont\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/julie-lafont\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lafont_julie_crcm.jpg\" alt=\"Julie Lafont - Reverse Molecular Pharmacology in Pediatric Oncology team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Julie Lafont<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/kevin-muller\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/muller_kevin_crcm.jpg\" alt=\"Kevin Muller - Reverse Molecular Pharmacology in Pediatric Oncology team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Kevin Muller<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lucile-revillod\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lucile-revillod\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/revillod_lucile_crcm.jpg\" alt=\"Lucile Revillod - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Lucile Revillod<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/manon-carre\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/manon-carre\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/carre_manon_crcm.jpg\" alt=\"Manon Carre - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Manon Carre<\/h2>\n\n<h4 class=\"wp-block-heading\">Lecturer and researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-pierre-montero\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-pierre-montero\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/montero_marie_pierre_crcm.jpg\" alt=\"Marie-Pierre Montero - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marie-Pierre Montero<\/h2>\n\n<h4 class=\"wp-block-heading\">Technician<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marion-le-grand\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marion-le-grand\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/le_grand_marion_crcm.jpg\" alt=\"Marion Le Grand - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marion Le Grand<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-kerherve\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-kerherve\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Mathilde Kerherv&#xE9;\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mathilde Kerherv\u00e9<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mohammed-taha\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mohammed-taha\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/taha_mohammed_crcm.jpg\" alt=\"Taha Mohammed - Reverse Molecular Pharmacology in Pediatric Oncology team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mohammed Taha<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/patricia-piris\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/patricia-piris\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Patricia Piris\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Patricia Piris<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-bourgarel\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-bourgarel\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Veronique-BOURGAREL-crcm.jpg\" alt=\"V&#xE9;ronique Bourgarel\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">V\u00e9ronique Bourgarel<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/arnauld-verschuur\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/arnauld-verschuur\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Arnaud-Verschuur-crcm.jpg\" alt=\"Arnauld Verschuur\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Arnauld Verschuur<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christine-roux\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christine-roux\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/roux_christine_crcm.jpg\" alt=\"Christine Roux - Reverse Molecular Pharmacology in Pediatric Oncology Team (REMAP-4kids) - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Christine Roux<\/h2>\n\n<h4 class=\"wp-block-heading\">Assistant Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/florent-sauteret\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/florent-sauteret\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Florent-SAUTERET-crcm.jpg\" alt=\"Florent Sauteret\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Florent Sauteret<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<h2 class=\"wp-block-heading\">Use existing drugs to reveal weaknesses in pediatric cancers and improve their management.<\/h2>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/remap-4kids-logo.png\" alt=\"REMAP 4kids team logo Translate-it department\"\/><\/figure>\n\n<p>The REMAP-4Kids team, led by biologist Dr Eddy Pasquier and oncopediatrician Prof Nicolas Andr\u00e9, draws on the complementary expertise of its members (research biologists, pharmacists and physicians) to establish a continuum from basic research to clinical studies.<\/p>\n\n<p><strong>Our projects focus on pediatric cancers.<\/strong>  The latter have their own pathophysiological characteristics, requiring dedicated research programs. In this context, we have developed an innovative concept of reverse molecular pharmacology, <strong>combining high-throughput pharmacological screening with pharmaco-proteomic approaches.<\/strong> Using existing drugs as molecular tools, our approach enables us to identify new combinatorial therapies and study their mechanisms of action. Firstly, we carry out high-throughput pharmacological screening in combination using customized drug libraries. This enables us to identify synergistic combinatorial treatments which are then validated in clinically relevant pediatric cancer models (i.e. 3D spheroids, patient tumoroids, ex vivo organotypic and in vivo orthotopic models). In addition, the interactome of each drug used alone or in combination is characterized by a pharmaco-proteomics method called <strong>&#8220;thermal proteome profiling&#8221;.<\/strong>    <\/p>\n\n<p>This unsupervised approach reveals the extent of drug poly-pharmacology (i.e. the action of a drug on several cellular targets in a specific pathological context) and identifies new vulnerabilities in pediatric cancers. Thanks to functional genomics techniques, the pathophysiological roles of new vulnerabilities, particularly in treatment resistance, are studied using a wide range of cell biology techniques. <\/p>\n\n<p><strong>In this way, we hope to advance our understanding of the molecular mechanisms of refractory pediatric tumors and develop more effective treatments.<\/strong><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/remap4kids-en.jpg\" alt=\"Image illustration Reverse molecular pharmacology in pediatric oncology team (REMAP-4kids) Translate-it CRCM department\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/image-equipe-pharmacologie-moleculaire-inversee-en-oncologie-pediatrique-REMAP-4kids.jpg\" alt=\"Image Reverse Molecular Pharmacology in Pediatric Oncology team (REMAP-4kids) Translate-it CRCM department\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/the-1st-edition-of-south-rocks-working-days\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Pasquier-News-1.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/team-pasquier-andre\/the-1st-edition-of-south-rocks-working-days\/\">The 1st edition of SOUTH-ROCK&#8217;s WORKING DAYS<\/a><\/h4>\n\n<p>SouthROCK is a consortium of excellence dedicated to pediatric cancer research, bringing together 250 experts from Lyon and Marseille. Its multidisciplinary work aims to accelerate scientific advances, improve care and prevent the side effects of treatment for sick children. <\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/category\/crcm-articles\/\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>09\/2023<\/p>\n\n<p><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(23)00317-1\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms. <\/a><\/p>\n\n<p>Ariey-Bonnet J, Berges R, Montero MP, Mouysset B, Piris P, Muller K, Pinna G, Failes TW, Arndt GM, Morando P, Baeza-Kallee N, Colin C, Chinot O, Braguer D, Morelli X, Andr\u00e9 N, Carr\u00e9 M, Tabouret E, Figarella-Branger D, Le Grand M, Pasquier E.<\/p>\n\n<p>09\/2023<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/trends\/cancer\/abstract\/S2405-8033(23)00099-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405803323000997%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">Holistic pediatric oncology: towards a second Copernican revolution. <\/a><\/p>\n\n<p>Andr\u00e9 N, Castets M, Pasquier E, Mehlen P.<\/p>\n\n<p>08\/2022<\/p>\n\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422003309\" target=\"_blank\" rel=\"noreferrer noopener\">Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma. <\/a><\/p>\n\n<p>Rossi M, Talbot J, Piris P, Grand ML, Montero MP, Matteudi M, Agavnian-Couquiaud E, Appay R, Keime C, Williamson D, Buric D, Bourgarel V, Padovani L, Clifford SC, Ayrault O, Pasquier E, Andr\u00e9 N, Carr\u00e9 M.<\/p>\n\n<p>04\/2024<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.canlet.2024.216800\" target=\"_blank\" rel=\"noreferrer noopener\">Poly-pharmacology of existing drugs: How to crack the code? <\/a><\/p>\n\n<p>Mouysset B, Le Grand M, Camoin L, Pasquier E.<\/p>\n\n<p>02\/2024<\/p>\n\n<p><a href=\"https:\/\/www.ejcancer.com\/article\/S0959-8049(24)00001-7\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">METRO-PD1: Phase 1 study of nivolumab in combination with metronomic chemotherapy in children and adolescents with relapsing\/refractory solid tumors. <\/a><\/p>\n\n<p>Andr\u00e9 N, Deley MCL, L\u00e9guillette C, Probst A, Willems L, Travers R, Aerts I, Faure-Conter C, Revond-Riviere G, Min V, Geoerger B, Chastagner P, Entz-Werl\u00e9 N, Leblond P.<\/p>\n\n<p>12\/2020<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1002\/1878-0261.12810\" target=\"_blank\" rel=\"noreferrer noopener\">In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor. <\/a><\/p>\n\n<p>Ariey-Bonnet J, Carrasco K, Le Grand M, Hoffer L, Betzi S, Feracci M, Tsvetkov P, Devred F, Collette Y, Morelli X, Ballester P, Pasquier E.<\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=((Pasquier%20E%5BAuthor%5D)%20OR%20(Andre%20N%5BAuthor%5D))%20AND%20((CRCM%5BAffiliation%5D)%20OR%20(Centre%20de%20Recherche%20en%20Cance%CC%81rologie%20de%20Marseille%5BAffiliation%5D)%20OR%20(Cancer%20Research%20Center%20of%20Marseille%5BAffiliation%5D))\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.wonderaugustine.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.associationcassandra.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.wonderaugustine.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.associationcassandra.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.wonderaugustine.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.associationcassandra.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/ariey_bonnet_jeremy_crcm.jpg\" alt=\"Ariey-Bonnet Jeremy Reverse molecular pharmacology in pediatric oncology team (REMAP-4kids) CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Jeremy Ariey-Bonnet<\/h5>\n\n<h5 class=\"wp-block-heading\">Post-doctoral researcher, Biotech Research &amp; Innovation Centre,<br\/>University of Copenhagen, Denmark<br\/>Master 2 then PharmD \/ PhD student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/compare_coralie_crcm.jpg\" alt=\"Compare Coralie - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Coralie Compare<\/h5>\n\n<h5 class=\"wp-block-heading\">Engineer<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/mouysset_baptiste_crcm.jpg\" alt=\"Mouysset Baptiste - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Baptiste Mouysset<\/h5>\n\n<h5 class=\"wp-block-heading\">Doctoral student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/matteudi_melanie_crcm.jpg\" alt=\"Matteudi M&#xE9;lanie - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">M\u00e9lanie Matteudi<\/h5>\n\n<h5 class=\"wp-block-heading\">Doctoral student<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/translate-it-department\/reverse-molecular-pharmacology-in-pediatric-oncology-team-remap-4kids-translate-it-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" 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[\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5912,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5916","page","type-page","status-publish","hentry"],"yoast_head":"<!-- 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