{"id":5904,"date":"2024-12-12T15:47:46","date_gmt":"2024-12-12T14:47:46","guid":{"rendered":"https:\/\/crcm-marseille.fr\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/"},"modified":"2026-04-13T10:06:06","modified_gmt":"2026-04-13T08:06:06","slug":"integrative-molecular-biology-in-hematopoiesis-and-leukemia","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia\/","title":{"rendered":"Integrative Molecular Biology in Hematopoiesis and Leukemia"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-ohio-crcm-1024x622.png\" alt=\"Logo Ohio department Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">Integrative molecular biology in hematopoiesis and leukemia<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-biologie-moleculaire-integrative-dans-lhematopoiese-et-la-leucemie-departement-ohio\/#\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/estelle-duprez\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/duprez_estelle_crcm.jpg?ver=1737470707\" alt=\"Estelle Duprez - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/estelle-duprez\/\">Estelle Duprez<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-loosveld\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-loosveld\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/loosveld_marie_crcm.jpg\" alt=\"Marie Loosveld - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marie Loosveld<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-poplineau\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-poplineau\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/poplineau_mathilde_crcm.jpg\" alt=\"Mathilde Poplineau - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mathilde Poplineau<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=1975\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mathis-nozais\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Mathis Nozais\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mathis Nozais<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-murati\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-murati\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/murati_anne_crcm.jpg\" alt=\"Murati Anne - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Anne Murati<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/charlotte-savay\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/charlotte-savay\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/savay_charlotte_crcm.jpg\" alt=\"Savay Charlotte - Marseille Cancer Research Center - Integrative Molecular Biology in Hematopoiesis and Leukemia Team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Charlotte Savay<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-taroni\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-taroni\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/taroni_chiara_crcm.jpg\" alt=\"Chiara Taroni - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Chiara Taroni<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&amp;p=1969\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&amp;p=1969\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Cl&#xE9;mence Grosjean\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Cl\u00e9mence Grosjean<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/delphine-potier\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/delphine-potier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/potier_delphine_crcm.jpg\" alt=\"Delphine Potier - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Delphine Potier<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/dominique-payet-bornet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/dominique-payet-bornet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/payet_dominique_crcm.jpg\" alt=\"Dominique Payet - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Dominique Payet-Bornet<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/julie-quessada\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/julie-quessada\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/quessada_julie_crcm.jpg\" alt=\"Julie Quessada - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Julie Quessada<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lia-nguyen\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lia-nguyen\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/nguyen_lia_crcm.jpg\" alt=\"Nguyen Lia - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Lia Nguyen<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/loreen-haboub\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/loreen-haboub\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/haboub_loreen_crcm.jpg\" alt=\"Haboub Loreen - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Loreen Haboub<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/maeva-rodies\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/maeva-rodies\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/rodies_maeva_crcm.jpg\" alt=\"Maeva Rodies - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Maeva Rodies<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-loosveld\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-loosveld\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/loosveld_marie_crcm.jpg\" alt=\"Marie Loosveld - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marie Loosveld<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-poplineau\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mathilde-poplineau\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/poplineau_mathilde_crcm.jpg\" alt=\"Mathilde Poplineau - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mathilde Poplineau<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=1975\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/mathis-nozais\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Mathis Nozais\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Mathis Nozais<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-murati\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/anne-murati\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/murati_anne_crcm.jpg\" alt=\"Murati Anne - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Anne Murati<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/charlotte-savay\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/charlotte-savay\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/savay_charlotte_crcm.jpg\" alt=\"Savay Charlotte - Marseille Cancer Research Center - Integrative Molecular Biology in Hematopoiesis and Leukemia Team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Charlotte Savay<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-taroni\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-taroni\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/taroni_chiara_crcm.jpg\" alt=\"Chiara Taroni - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Chiara Taroni<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<h2 class=\"wp-block-heading\">The Laboratory for Integrative Molecular Biology in Hematopoiesis and Leukemia deciphers the molecular mechanisms involved in the aging of hematopoietic stem cells, the initiation and development of leukemia and resistance to treatment.<\/h2>\n\n<p><strong>Our main objective<\/strong> is to discover the molecular networks involved in regulating the <strong>fate of normal or pathological hematopoietic cells<\/strong>, which may represent vulnerabilities to be targeted.<\/p>\n\n<p>Using mouse and cell models as well as patient samples, we integrate data from <strong>biochemical<\/strong>, <strong>epigenomic<\/strong> and <strong>omic<\/strong> approaches <strong>at the single-cell<\/strong> level to identify, characterize and manipulate key oncogenic pathways.<\/p>\n\n<p>We work mainly on :<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Acute myeloid leukemia<\/strong> and the<strong>accutisation of myeloproliferative disorders<\/strong> (PI: E. Duprez).<\/li>\n\n\n\n<li><strong>Acute T-cell lymphocytic leukemia<\/strong> (PI: D. Payet).<\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Estelle-duprez-illustration.png\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Estelle-duprez-illustration.png\" alt=\"Illustration - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">The projects<\/h2>\n\n<p>Theme 1: Mechanisms of hematopoietic aging<\/p>\n\n<p>Theme 2: Acute myeloid leukemia and treatment resistance<\/p>\n\n<p>Theme 3: Physiological and pathological differentiation of T lymphocytes<\/p>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/decouvrez-paroles-de-chercheurs-avec-frederic-bard-copy\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Poplineau2022-960x604.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/equipe-duprez\/decouvrez-paroles-de-chercheurs-avec-frederic-bard-copy\/\">Duprez team featured in Blood: cover story on epigenetic factors<\/a><\/h4>\n\n<p>Published by Poplineau et al. in 2022, the article &#8220;Noncanonical EZH2 drives retinoic acid resistance in AML by repressing retinoic acid targets&#8221; made the cover of the issue. <\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/category\/crcm-articles\/\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>12\/2022<\/p>\n\n<p><a href=\"https:\/\/ashpublications.org\/blood\/article\/140\/22\/2358\/486349\/Noncanonical-EZH2-drives-retinoic-acid-resistance\" target=\"_blank\" rel=\"noreferrer noopener\">Non-canonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias. <\/a><\/p>\n\n<p>Poplineau M, Platet N, Mazuel A, H\u00e9rault L, N&#8217;Guyen L, Koide S, Nakajima-Takagi Y, Kuribayashi W, Carbuccia N, Haboub L, Vernerey J, Oshima M, Birnbaum D, Iwama A, Duprez E.<\/p>\n\n<p>03\/2022<\/p>\n\n<p><a href=\"https:\/\/aacrjournals.org\/cancerdiscovery\/article\/12\/3\/774\/681925\/Pharmacologic-Reduction-of-Mitochondrial-Iron\" target=\"_blank\" rel=\"noreferrer noopener\">Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX\/BAK-Dependent Cell Death. <\/a><\/p>\n\n<p>Garciaz S, Guirguis AA, M\u00fcller S, Brown FC, Chan YC, Motazedian A, Rowe CL, Kuzich JA, Chan KL, Tran K, Smith L, MacPherson L, Liddicoat B, Lam EYN, Ca\u00f1eque T, Burr ML, Litalien V, Pomilio G, Poplineau M, Duprez E, Dawson SJ, Ramm G, Cox AG, Brown KK, Huang DCS, Wei AH, McArthur K, Rodriguez R, Dawson MA.<\/p>\n\n<p>02\/2021<\/p>\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-21168-6\" target=\"_blank\" rel=\"noreferrer noopener\">Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy. <\/a><\/p>\n\n<p>Rabilloud T, Potier D, Pankaew S, Nozais M, Loosveld M, Payet-Bornet D.<\/p>\n\n<p>05\/2019<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkz174\" target=\"_blank\" rel=\"noreferrer noopener\">PLZF limits enhancer activity during hematopoietic progenitor aging. <\/a><\/p>\n\n<p>Poplineau M, Vernerey J, Platet N, N&#8217;guyen L, H\u00e9rault L, Esposito M, Saurin AJ, Guilouf C, Iwama A, Duprez E.<\/p>\n\n<p>04\/2018<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1093\/nar\/gky080\" target=\"_blank\" rel=\"noreferrer noopener\">Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. <\/a><\/p>\n\n<p>Koubi M, Poplineau M, Vernerey J, N&#8217;Guyen L, Tiberi G, Garciaz S, El-Kaoutari A, Maqbool MA, Andrau JC, Guillouf C, Saurin AJ, Duprez E.<\/p>\n\n<p>04\/2016<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1182\/blood-2015-09-666974\" target=\"_blank\" rel=\"noreferrer noopener\">PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression. <\/a><\/p>\n\n<p>Vincent-Fabert C, Platet N, Vandevelde A, Poplineau M, Koubi M, Finetti P, Tiberi G, Imbert AM, Bertucci F, Duprez E.<\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28Duprez+E%5BAuthor%5D%29+AND+%28%28CRCM%5BAffiliation%5D%29+OR+%28Centre+de+Recherche+en+Cance%CC%81rologie+de+Marseille%5BAffiliation%5D%29+OR+%28Cancer+Research+Center+of+Marseille%5BAffiliation%5D%29%29&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/vincent_christelle_crcm.jpg\" alt=\"Vincent Christelle - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Christelle Vincent-Fabert<\/h5>\n\n<h5 class=\"wp-block-heading\">Post-doctoral researcher<br\/>Currently Researcher, Centre de Biologie en Recherche Limoges<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/tiberi_guillaume_crcm.jpg\" alt=\"Tiberi Guillaume - Integrative Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Guillaume Tiberi<\/h5>\n\n<h5 class=\"wp-block-heading\">Bioinfo engineer<br\/>Currently Bioinfo Python developer, consultant<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/koubi_myriam_crcm.jpg\" alt=\"Koubi Myriam - Integrative Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Myriam Koubi<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<br\/>Currently Research Engineer, University of Tours<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/zidi_bochra_crcm.jpg\" alt=\"Zibi Bochra - Integrative Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Bochra Zidi<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<br\/>Currently lecturer-researcher, University of Geneva<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/garcia_sylvain_crcm.jpg\" alt=\"Garcia Sylvain - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Sylvain Garciaz<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<br\/>Currently Senior Lecturer, Institut Paoli calmette<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/vernerey_julien_crcm-1.jpg\" alt=\"Vernerey Julien - Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Julien Vernerey<\/h5>\n\n<h5 class=\"wp-block-heading\">Bioinfo Engineer<br\/>Currently Research Engineer, Cibi Platform, CRCM<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/herault_leonard_crcm.jpg\" alt=\"H&#xE9;rault L&#xE9;onard - Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">L\u00e9onard Herault<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<br\/>Currently Post-doc University of Lausanne<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/mazuel_adrien_crcm.jpg\" alt=\"Mazuel Adrien - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Adrien Mazuel<\/h5>\n\n<h5 class=\"wp-block-heading\">Bioinfo engineer<br\/>Currently Research Engineer, CIML, Marseille<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/tellez_clara_crcm.jpg\" alt=\"Tellez Clara - Integrative Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Clara Tellez<\/h5>\n\n<h5 class=\"wp-block-heading\">PhD<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/burny_claie_crcm.jpg\" alt=\"Burny Claie - Integrative Molecular Biology Team - CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Claie Burny<\/h5>\n\n<h5 class=\"wp-block-heading\">Engineer<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/integrative-molecular-biology-in-hematopoiesis-and-leukemia-team-ohio-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights 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