{"id":5900,"date":"2024-11-21T09:37:43","date_gmt":"2024-11-21T08:37:43","guid":{"rendered":"https:\/\/crcm-marseille.fr\/ohio-department\/"},"modified":"2025-07-24T13:34:32","modified_gmt":"2025-07-24T11:34:32","slug":"ohio-department","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/ohio-department\/","title":{"rendered":"OHIO Department"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-picto-ohio-crcm.png\" alt=\"Ohio CRCM picto logo\"\/><\/figure>\n\n<h1 class=\"wp-block-heading\">oHIo<\/h1>\n\n<p>The <strong>OHIO<\/strong> Department, headed by <strong>Estelle Duprez and Raynier Devillier<\/strong>, comprises six teams focusing on<strong>hematology, immunology<\/strong> and <strong>innovative therapies<\/strong>.<br\/>With around 100 members, OHIO explores tumor mechanisms linked to the <strong>microenvironment and cellular heterogeneity<\/strong>, with the aim of overcoming treatment resistance.<br\/><br\/>In collaboration with <strong>the IPC<\/strong>, the department is developing a bidirectional<strong>&#8220;bench to bedside<\/strong>&#8221; approach, combining stem cell biology, immunotherapy and epigenetics. An important focus is <strong>acute myeloid leukemia<\/strong> (AML), where advanced technologies such as <strong>mass cytometry<\/strong> and <strong>single-cell analysis<\/strong> are identifying biomarkers and new therapies. <br\/><br\/>Treatments that reactivate<strong>NK cells<\/strong> are being studied. Thanks to a culture of collaboration between <strong>clinicians<\/strong> and <strong>researchers<\/strong>, OHIO enhances the visibility of its work and inspires clinical practice, while promoting interdisciplinary projects and scientific communication via the <strong>OHIOLetter<\/strong>. <\/p>\n\n<h2 class=\"wp-block-heading\">Department teams<\/h2>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/patrick-chames\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/Patrick-Chames.jpg?ver=1737458253\" alt=\"Patrick Chames - Therapeutic Antibodies and Immunoblotting Team (ATI) - Single-Domain Antibody Platform - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/patrick-chames\/\">Patrick Chames<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-anticorps-therapeutiques-et-immunociblage-ati-departement-ohio\/\">Antibody Therapeutics and Immunoblotting (ATI)<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/estelle-duprez\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/duprez_estelle_crcm.jpg?ver=1737470707\" alt=\"Estelle Duprez - Integrative Molecular Biology in Hematopoiesis and Leukemia Team - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/estelle-duprez\/\">Estelle Duprez<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-biologie-moleculaire-integrative-dans-lhematopoiese-et-la-leucemie-departement-ohio\/\"><strong>Integrative molecular biology in hematopoiesis and leukemia<\/strong><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/yves-collette\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/yves_colette_crcm_2.jpg\" alt=\"Collette Yves - Centre de recherche en canc&#xE9;rologie de Marseille - Structural Biology and Integrated Chemistry-Biology Team - TrGET Platform\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/xavier-morelli\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/morelli_xavier_crcm.jpg?ver=1737471117\" alt=\"Morelli Xavier - Structural Biology and Chemistry-Integrated Biology Team - HiTS Platform - High-throughput screening platform - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/yves-collette\/\">Yves Collette<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/xavier-morelli\/\">Xavier Morelli<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-biologie-structurale-et-chimie-biologie-integree-departement-ohio\/\">Structural Biology and Chemistry-Integrated Biology<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/jacques-nunes\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/jacques-nunes-140x140-1.jpg\" alt=\"Jacques Nunes Immunity and Cancer\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/raynier-devillier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/raynier-devillier-140x140-1.jpg\" alt=\"Raynier Devillier - Immunity and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jacques-nunes\/\">Jacques Nun\u00e8s<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/raynier-devillier\/\">Raynier Devillier<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-immunite-et-cancer-departement-ohio\/\">Immunity and Cancer<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/michel-aurrand-lions\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/aurrand-lions-michel-crcm.jpg?ver=1737545689\" alt=\"Aurrand-Lions Michel - Leuko\/Stromal Interactions in Normal and Pathological Hematopoiesis Team - ICEP Experimental Histopathology Platform - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/michel-aurrand-lions\/\">Michel Aurrand-Lions<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-interactions-leuco-stromales-dans-lhematopoiese-normale-et-pathologique-departement-ohio\/\">Leuko\/Stromal interactions in normal and pathological hematopoiesis<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/paulo-de-sepulveda\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/membre-equipe-crcm.jpg\" alt=\"Paulo De Sepulveda - Hematopoiesis Signaling and Mechanisms of Oncogenesis Team - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/paulo-de-sepulveda\/\">Paulo De Sepulveda<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/equipe-signalisation-hematopoiese-mecanismes-oncogenese-departement-ohio\/\">Signaling, Hematopoiesis and Mechanisms of Oncogenesis<\/a><\/strong><\/p>\n\n<h3 class=\"wp-block-heading\">The news<\/h3>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/interview-with-rima-kochman-doctoral-student-in-the-coulon-team\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/article-interview-rima-kochman-doctorante-crcm.jpg\" alt=\"Article interview with Rima Kochman doctoral student - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/interview-de-rima-kochman-doctorante-au-sein-de-lequipe-coulon\/\">Interview with Rima Kochman, doctoral student in the Coulon team<\/a><\/h5>\n\n<p>Rima Kochman from the Coulon team was one of the doctoral students who stood out with her thesis project. &#8220;Heterozygous RPA2 variant [&#8230;] <\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/more-than-26-articles-published-in-just-a-few-months-by-crcm-teams\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/publications-scientifiques-crcm.jpg\" alt=\"Scientific publications - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/plus-de-26-articles-publies-en-quelques-mois-par-les-equipes-crcm\/\">More than 26 articles published in just a few months by CRCM teams!<\/a><\/h5>\n\n<p>Once again, CRCM members have been very productive, with no fewer than 26 articles published [&#8230;].<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">SEE MORE<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">The events<\/h3>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">see more<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">our other areas of research<\/h3>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-genome-integrity-crcm.png\" alt=\"Genome Integrity department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-translate-it\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-translate-it-crcm-1.png#846\" alt=\"\" title=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-comet-crcm.png#591\" alt=\"\" title=\"\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/ohio-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" 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[\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5900","page","type-page","status-publish","hentry"],"yoast_head":"<!-- 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