{"id":5898,"date":"2024-12-10T11:39:00","date_gmt":"2024-12-10T10:39:00","guid":{"rendered":"https:\/\/crcm-marseille.fr\/genome-integrity-department\/telomeres-and-chromatin-team-genome-integrity-department\/"},"modified":"2026-02-18T16:50:48","modified_gmt":"2026-02-18T15:50:48","slug":"telomeres-and-chromatin","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/","title":{"rendered":"Telomeres and Chromatin"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-genome-integrity-crcm.png#592\" alt=\"\" title=\"\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">Telomeres and<br\/>chromatin<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin-team-genome-integrity-department\/#\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/stephane-coulon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/coulon_stephane_crcm_2.jpg?ver=1737456815\" alt=\"St&#xE9;phane Coulon CRCM - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/stephane-coulon\/\">Stephane Coulon<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/valeria-rubeo\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/valeria-rubeo\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/rubeo_valeria_crcm.jpg\" alt=\"Rubeo Valeria - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Valeria Rubeo<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=2002\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/valerie-garcia\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/garcia_valerie_crcm.jpg\" alt=\"Garcia Val&#xE9;rie - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Val\u00e9rie Garcia<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/yves-corda\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yves-corda\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/corda_yves_crcm.jpg\" alt=\"Corda yves Centre de Recherche en Canc&#xE9;rologie de Marseille - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yves Corda<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/alexandre-de-nonneville\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/alexandre-de-nonneville\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/de_nonnevillealexandre_crcm.jpg\" alt=\"De Nonneville Alexandre Centre de Recherche en Canc&#xE9;rologie de Marseille\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Alexandre de Nonneville<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/asako-isogawa\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/asako-isogawa\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/isogawa_asako_crcm.jpg\" alt=\"Isogawa asako - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Asako Isogawa<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=1996\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chainez-bouabboune\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Cha&#xEF;nez Bouabboune\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Cha\u00efnez Bouabboune<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christelle-cayrou\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christelle-cayrou\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/cayrou_christelle_crcm.jpg\" alt=\"Cayrou Christelle - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Christelle Cayrou<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-de-la-roche-saint-andre\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-de-la-roche-saint-andre\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/de-la-roche-saint-andre-christophe_crcm.jpg\" alt=\"Christophe De La Roche Saint-Andr&#xE9; - Telomeres and Chromatin Team CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Christophe De la Roche Saint Andr\u00e9<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/coline-hamelin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/coline-hamelin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/hamelin_coline_crcm.jpg\" alt=\"Hamelin Coline - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Coline Hamelin<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/dmitri-churikov\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/dmitri-churikov\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/churikov_dmitri_crcm_2.jpg\" alt=\"Churikov Dmitri Centre de Recherche en Canc&#xE9;rologie de Marseille - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Dmitri Churikov<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/francois-laffont\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/francois-laffont\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/laffont_francois_crcm.jpg\" alt=\"Fran&#xE7;ois Laffont - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Fran\u00e7ois Laffont<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/frederic-jourquin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/frederic-jourquin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/jourquin_frederic_crcm_2.jpg\" alt=\"Jourquin Fr&#xE9;d&#xE9;ric Centre de Recherche en Canc&#xE9;rologie de Marseille - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Fr\u00e9d\u00e9ric Jourquin<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jerome-robin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/jerome-robin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/robin_jerome_crcm.jpg\" alt=\"Robin J&#xE9;r&#xF4;me - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">J\u00e9r\u00f4me Robin<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/karel-naiman\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/karel-naiman\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Karel Naiman\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Karel Naiman<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lea-seban\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lea-seban\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/seban_lea_crcm.jpg\" alt=\"Seban L&#xE9;a - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">L\u00e9a Seban<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/manon-pierre\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/manon-pierre\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/pierre_manon_crcm.jpg\" alt=\"Pierre Manon - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Manon Pierre<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-noelle-simon\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marie-noelle-simon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/simon_marie_noelle_crcm.jpg\" alt=\"Simon Marie-No&#xEB;lle Centre de Recherche en Canc&#xE9;rologie de Marseille - Telomeres and Chromatin Team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marie-No\u00eblle Simon<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/pierre-luciano\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/pierre-luciano\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/luciano_pierre_crcm.jpg\" alt=\"Luciano Pierre - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Pierre Luciano<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/valeria-rubeo\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/valeria-rubeo\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/rubeo_valeria_crcm.jpg\" alt=\"Rubeo Valeria - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Valeria Rubeo<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=2002\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/valerie-garcia\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/garcia_valerie_crcm.jpg\" alt=\"Garcia Val&#xE9;rie - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Val\u00e9rie Garcia<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/yves-corda\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yves-corda\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/corda_yves_crcm.jpg\" alt=\"Corda yves Centre de Recherche en Canc&#xE9;rologie de Marseille - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yves Corda<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/alexandre-de-nonneville\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/alexandre-de-nonneville\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/de_nonnevillealexandre_crcm.jpg\" alt=\"De Nonneville Alexandre Centre de Recherche en Canc&#xE9;rologie de Marseille\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Alexandre de Nonneville<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/asako-isogawa\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/asako-isogawa\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/isogawa_asako_crcm.jpg\" alt=\"Isogawa asako - Telomeres and chromatin team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Asako Isogawa<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/?post_type=sptp_member&#038;p=1996\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chainez-bouabboune\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"Cha&#xEF;nez Bouabboune\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Cha\u00efnez Bouabboune<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<h2 class=\"wp-block-heading\">The Telomeres and Chromatin Laboratory studies telomere maintenance mechanisms in relation to cancer, aging and telomeropathies.<\/h2>\n\n<p><strong> Telomeres<\/strong> are nucleoprotein structures at the ends of chromosomes that preserve genome stability and function. Telomere biology is closely linked to <strong>cell senescence<\/strong>, stem cell biology and <strong>cancer development<\/strong>. <\/p>\n\n<p>The team studies in yeast models <strong>the mechanisms that maintain telomere length<\/strong>, telomere replication, and cellular responses to telomere erosion. Our work focuses in particular on <strong>the relocation of eroded telomeres to the Nuclear Pore<\/strong> during replicative senescence and the functional consequences of this relocation. <\/p>\n\n<p>The laboratory is part of a consortium that aims to identify the genes responsible for telomeropathies, rare genetic diseases caused by premature telomere shortening. We aim to understand how these genes are involved in telomere maintenance. <\/p>\n\n<p>The team is also involved in a number of cancer-fighting programs.  <strong>In particular, we are studying the mechanism of alternative telomere lengthening (ALT) in tumors of mesenchymal origin lacking ATRX mutations.<\/strong><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/image-equipe-telomere-et-chromatine.jpg\" alt=\"Image Telomeres and chromatin team CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/image-illustration-equipe-telomeres-et-chtomatine-crcm.jpg\" alt=\"Illustration of the Telomeres and Chromatin team - Centre de Recherche en Canc&#xE9;rologie de Marseille\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">The projects<\/h2>\n\n<p>Temporal and spatial regulation of replication forks at telomeres<\/p>\n\n<p>Telomeropathies<\/p>\n\n<p>Deciphering the mechanism of ALT in pediatric osteosarcomas (OS)<\/p>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/coulon-team-identifies-heterozygous-rpa2-variant-as-new-cause-of-telomere-biology-disorders\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Coulon-News-2.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/scientific-publication\/coulon-team-identifies-heterozygous-rpa2-variant-as-new-cause-of-telomere-biology-disorders\/\">In Press : Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders<\/a><\/h4>\n\n<p>This study identifies a mutation in the RPA2 gene (c.767A&gt;G; Y256C) as a novel genetic cause of telomere biology disorders (TBDs). The mutation alters telomere regulation, leading to telomere shortening. Partial somatic rescue events have been observed in patients.  <\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/the-telomeres-and-chromatin-group-coulon-team-joins-the-marmara-institute\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Coulon-News-1.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/the-coulon-team\/the-telomeres-and-chromatin-group-coulon-team-joins-the-marmara-institute\/\">Telomeres and chromatin team joins Institut MarMaRa<\/a><\/h4>\n\n<p>The MarMaRa Institute, which brings together over 30 interdisciplinary research teams, now welcomes the Telomeres and Chromatin team. This partnership will strengthen research into rare diseases, combining genetics, systems biology and therapeutic innovations to improve diagnosis and treatment. <\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/category\/crcm-articles\/\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>09\/2024<\/p>\n\n<p><a href=\"https:\/\/genesdev.cshlp.org\/content\/38\/15-16\/755\" target=\"_blank\" rel=\"noreferrer noopener\">Heterozygous <em>RPA2<\/em> variant as a novel genetic cause of telomere biology disorders. Genes Dev. <\/a><\/p>\n\n<p>Kochman R, Ba I, Yates M, Pirabakaran V, Gourmelon F, Churikov D, Laffaille M, Kermasson L, Hamelin C, Marois I, Jourquin F, Braud L, Bechara M, Lainey E, Nunes H, Breton P, Penhouet M, David P, G\u00e9li V, Lachaud C, Mar\u00e9chal A, Revy P, Kannengiesser C, Saintom\u00e9 C, Coulon S.<\/p>\n\n<p>06\/2023<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112537\" target=\"_blank\" rel=\"noreferrer noopener\">Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast. <\/a><\/p>\n\n<p>Vaurs M, Naiman K, Bouabboune C, Rai S, Ptasi\u0144ska K, Rives M, Matmati S, Carr AM, G\u00e9li V, Coulon S.<\/p>\n\n<p>03\/2022<\/p>\n\n<p><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/embj.2021108736\" target=\"_blank\" rel=\"noreferrer noopener\">Telomeric C-circles localize at nuclear pore complexes in Saccharomyces cerevisiae. <\/a><\/p>\n\n<p>Aguilera P, Dubarry M, Hardy J, Lisby M, Simon MN, G\u00e9li V.<\/p>\n\n<p>08\/2022<\/p>\n\n<p><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.202215859\" target=\"_blank\" rel=\"noreferrer noopener\">TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT. <\/a><\/p>\n\n<p>de Nonneville A, Salas S, Bertucci F, Sobinoff AP, Ad\u00e9la\u00efde J, Guille A, Finetti P, Noble JR, Churikov D, Chaffanet M, Lavit E, Pickett HA, Bouvier C, Birnbaum D, Reddel RR, G\u00e9li V.<\/p>\n\n<p>11\/2022<\/p>\n\n<p><a href=\"https:\/\/academic.oup.com\/nar\/article\/50\/20\/11682\/6795888\" target=\"_blank\" rel=\"noreferrer noopener\">A proto-telomere is elongated by telomerase in a shelterin-dependent manner in quiescent fission yeast cells. <\/a><\/p>\n\n<p>Vaurs M, Audry J, Runge KW, G\u00e9li V, Coulon S.<\/p>\n\n<p>03\/2020<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2020.02.065\" target=\"_blank\" rel=\"noreferrer noopener\">Telomerase Repairs Collapsed Replication Forks at Telomeres. <\/a><\/p>\n\n<p>Matmati S, Lambert S, G\u00e9li V, Coulon S.<\/p>\n\n<p>01\/2020<\/p>\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13979-5\" target=\"_blank\" rel=\"noreferrer noopener\">The nuclear pore complex prevents sister chromatid recombination during replicative senescence. <\/a><\/p>\n\n<p>Aguilera P, Whalen J, Minguet C, Churikov D, Freudenreich C, Simon MN, G\u00e9li V.<\/p>\n\n<p><a href=\"https:\/\/tinyurl.com\/3xwkb8rj\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/anr.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/canceropole-paca.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/gadam_nicolas_crcm.jpg\" alt=\"Gadam Nathan - Marseille Cancer Research Center - Telomeres and Chromatin Team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Nathan Gadam<\/h5>\n\n<h5 class=\"wp-block-heading\">Post doctoral student in Jessica Downs&#8217;s group<br\/>The Institute of Cancer Research (ICR), London UK<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/vaurs_melina_crcm.jpg\" alt=\"Vaurs M&#xE9;lina - Marseille Cancer Research Center - Telomeres and Chromatin Team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">M\u00e9lina Vaurs<\/h5>\n\n<h5 class=\"wp-block-heading\">Post doctoral student in Anabelle Decottignies Lab<br\/>Institut de Duve Avenue Hippocrate 75 &#8211; B1.75.04 1200 Brussels<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/matmati_samah_crcm.jpg\" alt=\"Matmati Samah - Marseille Cancer Research Center - Telomeres and chromatin team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Samah Matmati<\/h5>\n\n<h5 class=\"wp-block-heading\">Post doctoral student in Joachim Lingner Lab<br\/>EPFL , Lausanne, Switzerland<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/aguilera_paula_crcm.jpg\" alt=\"Aguilera Paula - Marseille Cancer Research Center - Telomeres and Chromatin Team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Paula Aguilera<\/h5>\n\n<h5 class=\"wp-block-heading\">Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER),<br\/>Consejo Superior de Investigaciones Cientificas (CSIC),<br\/>Universidad de Sevilla, Universidad Pablo de Olavide, Seville, Spain<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/audry_julien_crcm.jpg\" alt=\"Audry Julien - Centre de recherche en canc&#xE9;rologie de Marseille - Telomeres and chromatin team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Julien Audry<\/h5>\n\n<h5 class=\"wp-block-heading\">Scientist R&amp;D Assay Development Nexelis<br\/>Montr\u00e9al, Qu\u00e9bec, Canada<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/telomeres-and-chromatin-team-genome-integrity-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a> &amp; <a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Telomeres andchromatin Paoli Calmettes Institute Stephane Coulon Team manager Valeria Rubeo Doctoral student Val\u00e9rie<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5886,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5898","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - 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