{"id":5894,"date":"2024-11-28T13:50:04","date_gmt":"2024-11-28T12:50:04","guid":{"rendered":"https:\/\/crcm-marseille.fr\/genome-integrity-department\/dna-damage-and-blood-diseases-team-genome-integrity-department\/"},"modified":"2025-06-23T14:02:28","modified_gmt":"2025-06-23T12:02:28","slug":"dna-damages-and-blood-disorders","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/dna-damages-and-blood-disorders\/","title":{"rendered":"DNA damages and blood disorders\u00a0"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-genome-integrity-crcm.png#592\" alt=\"\" title=\"\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">DNA damage and blood disorders<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/x.com\/lablachaud\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-lachaud\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lachaud_christophe_crcm.jpg?ver=1737456749\" alt=\"Christophe Lachaud CRCM - Strand-bridging DNA damage and blood disorders team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-lachaud\/\">Christophe Lachaud<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lara-lee\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lara-lee\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lee_lara_crcm.jpg\" alt=\"Lara Lee CRCM - DNA Damage and Blood Diseases Team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Lara Lee<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/laura-braud\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/laura-braud\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/braud_laura_crcm.jpg\" alt=\"Laura Braud CRCM - Telomeres and Chromatin Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Laura Braud<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/yost-hicheri\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yost-hicheri\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/yosr_hicheri_crcm.jpg\" alt=\"Yosr Hicheri CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yosr Hicheri<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/arthur-sterin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/arthur-sterin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/sterin_arthur_crcm.jpg\" alt=\"Sterin Arthur CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Arthur Sterin<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Researcher-Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/gilles-audoly\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/gilles-audoly\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/audoly_gilles_crcm.jpg\" alt=\"Gilles Audoly CRCM - DNA damage by strand-bridging and blood disorders team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Gilles Audoly<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/hagay-sobol\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/hagay-sobol\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/hagay_sobol_crcm.jpg\" alt=\"Hagay Sobol CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Hagay Sobol<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Researcher-Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jean-hugues-guervilly\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/jean-hugues-guervilly\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/guervilly_jean_hugues_crcm-1.jpg\" alt=\"Jean-Hugues Guervilly CRCM - - Strand-bridging DNA damage and blood disorders team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Jean-Hugues Guervilly<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/lara-lee\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/lara-lee\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lee_lara_crcm.jpg\" alt=\"Lara Lee CRCM - DNA Damage and Blood Diseases Team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Lara Lee<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/laura-braud\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/laura-braud\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/braud_laura_crcm.jpg\" alt=\"Laura Braud CRCM - Telomeres and Chromatin Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Laura Braud<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/yost-hicheri\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/yost-hicheri\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/yosr_hicheri_crcm.jpg\" alt=\"Yosr Hicheri CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Yosr Hicheri<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher &#8211; Hospital practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/arthur-sterin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/arthur-sterin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/sterin_arthur_crcm.jpg\" alt=\"Sterin Arthur CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Arthur Sterin<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Researcher-Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/gilles-audoly\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/gilles-audoly\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/audoly_gilles_crcm.jpg\" alt=\"Gilles Audoly CRCM - DNA damage by strand-bridging and blood disorders team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Gilles Audoly<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/hagay-sobol\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/hagay-sobol\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/hagay_sobol_crcm.jpg\" alt=\"Hagay Sobol CRCM DNA damage by strand-bridging and blood diseases team\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Hagay Sobol<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Researcher-Practitioner<\/h4>\n\n<h2 class=\"wp-block-heading\">Our team brings together the expertise of biologists, clinicians and chemists to develop new tools and improve our understanding of DNA repair mechanisms, particularly in the context of diagnosing and treating blood disorders.<\/h2>\n\n<p>Our team conducts multidisciplinary research aimed at<strong> deciphering the fundamental mechanisms involved in genome stability and the response to DNA damage<\/strong>, with particular emphasis on their implications in oncology and hematology. Through innovative approaches combining molecular biology, biochemistry and chemistry, we explore DNA repair processes, in particular the Fanconi anemia\/BRCA pathway, and mechanisms of resistance to chemotherapeutic agents. We also analyze the role of UFMylation, a post-translational modification, in maintaining genomic integrity. We are also studying the interactions between medullary adipose tissue and hematopoietic cells in normal and pathological contexts.   <\/p>\n\n<p>In addition to these fundamental aspects, our research has a translational perspective, with the aim of transferring our discoveries to clinical applications. Thanks to our collaborations with chemists, clinicians and bioinformaticians, we are developing innovative diagnostic tools and exploring new targeted therapeutic approaches.   <strong>The aim of our work is to improve the management of patients suffering from hematological and cancerous diseases by proposing more effective and better-tolerated strategies.<\/strong>  Among other things, we are developing messenger RNA-based therapeutic strategies to correct hematopoietic dysfunctions in congenital anemias.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/dna-equipe-lesions-de-l-adn-crcm.jpg\" alt=\"Illustration - DNA strand breaks and blood diseases team - CRCM\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">The projects<\/h2>\n\n<p>Detection of DNA strand bridges and characterization of their repair<\/p>\n\n<p>Impact of FAN1 on chemotherapy resistance<\/p>\n\n<p>The role of UFMylation in maintaining genome stability and responding to DNA damage<\/p>\n\n<p>Medullary adipose tissue in normal and pathological hematopoiesis<\/p>\n\n<p>Messenger RNA therapeutic approach to normalize erythrocyte maturation in congenital anemia (NANEMIAR Project)<\/p>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/christophe-lachaud-organizes-a-solidarity-karaoke-evening-at-the-blackstone\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Karaoke-crcm.jpeg\" alt=\"Karaoke - Strand-bridging DNA damage and blood disorders team - CRCM\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/equipe-lachaud\/une-soiree-karaoke-solidaire-organisee-par-christophe-lachaud-au-blackstone\/\">Christophe Lachaud organizes a karaoke evening for solidarity at the Blackstone<\/a><\/h4>\n\n<p>Organized by Christophe Lachaud, the evening raised funds for the IPC, supporting the CRCM\/IOC in their fight against cancer. A great success, combining solidarity and conviviality. <\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/#\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>03\/2024<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae001\" target=\"_blank\" rel=\"noreferrer noopener\">STIM1 translocation to the nucleus protects cells from DNA damage. <\/a><\/p>\n\n<p>Sanchez-Lopez I, Orantos-Aguilera Y, Pozo-Guisado E, Alvarez-Barrientos A, Lilla S, Zanivan S, Lachaud C, Martin-Romero FJ.<\/p>\n\n<p>08\/2023<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad559\" target=\"_blank\" rel=\"noreferrer noopener\">A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells. <\/a><\/p>\n\n<p>Berrada S, Mart\u00ednez-Balsalobre E, Larcher L, Azzoni V, Vasquez N, Da Costa M, Abel S, Audoly G, Lee L, Montersino C, Castellano R, Combes S, Gelot C, Ceccaldi R, Guervilly JH, Soulier J, Lachaud C.<\/p>\n\n<p>07\/2023<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.blre.2023.101094\" target=\"_blank\" rel=\"noreferrer noopener\">Beyond current treatment of Fanconi Anemia: What do advances in cell and gene-based approaches offer? <\/a><\/p>\n\n<p>Mart\u00ednez-Balsalobre E, Guervilly JH, van Asbeck-van der Wijst J, P\u00e9rez-Oliva AB, Lachaud C.<\/p>\n\n<p>09\/2021<\/p>\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abc7371\" target=\"_blank\" rel=\"noreferrer noopener\">UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. <\/a><\/p>\n\n<p>Lee L, Perez Oliva AB, Martinez-Balsalobre E, Churikov D, Peter J, Rahmouni D, Audoly G, Azzoni V, Audebert S, Camoin L, Mulero V, Cayuela ML, Kulathu Y, Geli V, Lachaud C.<\/p>\n\n<p>06\/2017<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(17)30277-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276517302770%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health. <\/a><\/p>\n\n<p>Feeney L, Mu\u00f1oz IM, Lachaud C, Toth R, Appleton PL, Schindler D, Rouse J<\/p>\n\n<p>02\/2016<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1126\/science.aad5634\" target=\"_blank\" rel=\"noreferrer noopener\">Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability. <\/a><\/p>\n\n<p>Lachaud C, Moreno A, Marchesi F, Toth R, Blow JJ, Rouse J.<\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28Lachaud+C%5BAuthor%5D%29+AND+%28%28CRCM%5BAffiliation%5D%29+OR+%28Centre+de+Recherche+en+Cance%CC%81rologie+de+Marseille%5BAffiliation%5D%29+OR+%28Cancer+Research+Center+of+Marseille%5BAffiliation%5D%29%29&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/gemael_cedrick_taty_taty_crcm.jpg\" alt=\"Gema&#xEB;l cedrick Taty Taty CRCM - DNA damage by strand-bridging and blood disorders team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Gemael Cedrick Taty Taty<\/h5>\n\n<h5 class=\"wp-block-heading\">Clinical Research Associate (ARC\/TEC)<br\/>Tempo Pharma, France<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/sara_berrada_crcm.jpg\" alt=\"Sara Berrada crcm - DNA damage by strand-bridging and blood diseases team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Sara Berrada<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral researcher<br\/>Quebec, Canada<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/azzoni_violette_crcm.jpg\" alt=\"Azzoni Violette CRCM - DNA damage by strand-bridging and blood disorders team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Violette Azzoni<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral researcher<br\/>Copenhagen, Denmark<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/elena_martinez_balsalobre_crcm.jpg\" alt=\"Elena Martinez Balsalobre CRCM - DNA strand breaks and blood disorders team\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Elena Martinez Balsalobre<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral researcher<br\/>Murcia, Spain<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a> &amp; <a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA damage and blood disorders Paoli Calmettes Institute Christophe Lachaud Team manager Lara Lee<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5886,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5894","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - 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