{"id":5886,"date":"2024-10-01T12:28:05","date_gmt":"2024-10-01T10:28:05","guid":{"rendered":"https:\/\/crcm-marseille.fr\/genome-integrity-department\/"},"modified":"2025-09-25T16:52:00","modified_gmt":"2025-09-25T14:52:00","slug":"genome-integrity-department","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/","title":{"rendered":"Genome Integrity Department"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">For students<\/a>\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Studying at CRCM<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Thesis \/ Master offers<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Our training courses<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Mentoring<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Student Association<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Seminars<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/genome-integrity-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-picto-genome-integrity-crcm.png\" alt=\"Logo picto Genome Integrity CRCM\"\/><\/figure>\n\n<h1 class=\"wp-block-heading\">Genome Integrity<\/h1>\n\n<p>The <strong>Genome Integrity<\/strong> Department, which grew out of the IGC Unit founded in 2006, studies the mechanisms of<strong>DNA<\/strong> replication, repair and recombination. Comprising <strong>six teams,<\/strong> it explores the impact of DNA damage on cancer and aging.<br\/>This research aims to better <strong>understand the genomic instability<\/strong> of tumor cells and develop new therapeutic strategies targeting their Achilles heel: their dependence on <strong>genome protection<\/strong>mechanisms <strong>.<br\/><br\/><\/strong>The department uses innovative approaches such as real-time observation of DNA repair<strong> nanomachines<\/strong>, using optical tweezers and <strong>advanced<\/strong> <strong>microscopy techniques<\/strong>. <br\/>Active in basic and translational research, he collaborates with <strong>clinicians<\/strong> and trains <strong>students<\/strong> in cutting-edge techniques, contributing to internationally renowned publications and enriching knowledge about    <strong>genomic stability.<\/strong><\/p>\n\n<h2 class=\"wp-block-heading\">Department teams<\/h2>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/pierre-henri-gaillard\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/gaillard_pierre_henri_crcm.jpg?ver=1737450821\" alt=\"Pierre-Henri Gaillard CRCM - Structure-Specific Endonuclease Control and Genome Stability Team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/pierre-henri-gaillard\/\">Pierre-Henri Gaillard<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-controle-des-endonucleases-a-specificite-de-structure-et-stabilite-du-genome-departement-genome-integrity\/\">Control of Structure-Specific Endonucleases and Genome Stability<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/vincent-pages\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/pages_vincent_crcm.jpg\" alt=\"Vincent Pages CRCM - DNA damage and genome instability team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/vincent-pages\/\">Vincent Pag\u00e8s<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-dommage-adn-instabilite-genome-departement-genome-integrity\/\">DNA damage and genome instability<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/bertrand-llorente\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/llorente_bertrand_crcm_3.jpg\" alt=\"Llorente Bertrand - Marseille Cancer Research Center - Genome Dynamics and Recombination Team - Integrative Bioinformatics Platform\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/bertrand-llorente\/\">Bertrand Llorente<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-dynamique-du-genome-et-recombinaison-departement-genome-integrity\/\">Genome Dynamics and Recombination  <\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/christophe-lachaud\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lachaud_christophe_crcm.jpg?ver=1737456749\" alt=\"Christophe Lachaud CRCM - Strand-bridging DNA damage and blood disorders team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-lachaud\/\">Christophe Lachaud<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-lesions-de-ladn-par-pontage-inter-brin-et-maladies-du-sang-departement-genome-integrity\/\">Strand-bridging DNA damage and blood disorders<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/mauro-modesti\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/picto-sans-image.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/mauro-modesti\/\">Mauro Modesti<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-recombinaison-homologue-nhej-et-sauvegarde-de-lintegrite-genomique-departement-genome-integrity\/\">Homologous recombination, NHEJ and safeguarding genomic integrity<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/stephane-coulon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/coulon_stephane_crcm_2.jpg?ver=1737456815\" alt=\"St&#xE9;phane Coulon CRCM - Telomeres and chromatin team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/stephane-coulon\/\">Stephane Coulon<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/equipe-telomeres-et-chromatine-departement-genome-integrity\/\">Telomeres and chromatin<\/a><\/strong><\/p>\n\n<h3 class=\"wp-block-heading\">The news<\/h3>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/interview-with-rima-kochman-doctoral-student-in-the-coulon-team\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/article-interview-rima-kochman-doctorante-crcm.jpg\" alt=\"Article interview with Rima Kochman doctoral student - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/interview-de-rima-kochman-doctorante-au-sein-de-lequipe-coulon\/\">Interview with Rima Kochman, doctoral student in the Coulon team<\/a><\/h5>\n\n<p>Rima Kochman from the Coulon team was one of the doctoral students who stood out with her thesis project. &#8220;Heterozygous RPA2 variant [&#8230;] <\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/more-than-26-articles-published-in-just-a-few-months-by-crcm-teams\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/publications-scientifiques-crcm.jpg\" alt=\"Scientific publications - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/plus-de-26-articles-publies-en-quelques-mois-par-les-equipes-crcm\/\">More than 26 articles published in just a few months by CRCM teams!<\/a><\/h5>\n\n<p>Once again, CRCM members have been very productive, with no fewer than 26 articles published [&#8230;].<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">SEE MORE<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">The events<\/h3>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">see more<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">our other areas of research<\/h3>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-comet-crcm.png\" alt=\"Comet department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-ohio-crcm.png\" alt=\"Logo Ohio department Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-translate-it\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-translate-it-crcm-1.png\" alt=\"Translate-it department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul 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