{"id":5882,"date":"2024-12-04T12:27:53","date_gmt":"2024-12-04T11:27:53","guid":{"rendered":"https:\/\/crcm-marseille.fr\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/"},"modified":"2025-06-23T14:01:04","modified_gmt":"2025-06-23T12:01:04","slug":"heme-ubiquitin-and-lung-cancer","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer\/","title":{"rendered":"Heme, Ubiquitin, and Lung Cancer"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-comet-crcm-1024x622.png\" alt=\"Comet department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">Heme, Ubiquitin and Lung Cancer<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/#\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/luca-lignitto\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/lignitto_luca_crcm.jpg?ver=1737387804\" alt=\"Lignitto Lucas - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/luca-lignitto\/\">Luca Lignitto<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jack-jordan\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/jack-jordan\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/jack_jordan_crcm.jpg\" alt=\"Jack Jordan - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Jack Jordan<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/josephine-shabani\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/josephine-shabani\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/shabani_josephine_crcm.jpg\" alt=\"Shabani Jos&#xE9;phine Heme, Ubiquitin and Lung Cancer team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Josephine Shabani<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/sonia-ines-mimoune\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/sonia-ines-mimoune\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/mimoune_ines_crcm.jpg\" alt=\"Mimoune Ines - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Sonia In\u00e8s Mimoune<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/bashir-ahmed\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/bashir-ahmed\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/bashir_ahmed_crcm.jpg\" alt=\"Bashir Ahmed - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Bashir Ahmed<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-pastorello\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-pastorello\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/pastorello_chiara_crcm-1.jpg\" alt=\"Pastorello Chiara Heme, Ubiquitin and Lung Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Chiara Pastorello<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/daniele-salaun\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/daniele-salaun\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/salaun_daniele_crcm.jpg\" alt=\"Salaun Dani&#xE8;le - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Dani\u00e8le Salaun<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jack-jordan\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/jack-jordan\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/jack_jordan_crcm.jpg\" alt=\"Jack Jordan - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Jack Jordan<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-doctoral fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/josephine-shabani\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/josephine-shabani\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/shabani_josephine_crcm.jpg\" alt=\"Shabani Jos&#xE9;phine Heme, Ubiquitin and Lung Cancer team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Josephine Shabani<\/h2>\n\n<h4 class=\"wp-block-heading\">Master 2 student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/sonia-ines-mimoune\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/sonia-ines-mimoune\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/mimoune_ines_crcm.jpg\" alt=\"Mimoune Ines - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Sonia In\u00e8s Mimoune<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/bashir-ahmed\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/bashir-ahmed\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/bashir_ahmed_crcm.jpg\" alt=\"Bashir Ahmed - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Bashir Ahmed<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-pastorello\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chiara-pastorello\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/pastorello_chiara_crcm-1.jpg\" alt=\"Pastorello Chiara Heme, Ubiquitin and Lung Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Chiara Pastorello<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/daniele-salaun\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/daniele-salaun\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/salaun_daniele_crcm.jpg\" alt=\"Salaun Dani&#xE8;le - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Dani\u00e8le Salaun<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<h2 class=\"wp-block-heading\">The overall aim of our laboratory is to discover how the signaling system controlled by the heme molecule regulates the life of intact cells and organisms. We want to explore its relationship with oxidative stress and dissect the role of this molecular axis in the mechanisms of cancer formation and evolution. <\/h2>\n\n<p>While heme has been known for decades as an indispensable prosthetic group that enabled the development of aerobic life, more recent discoveries have demonstrated that heme also exists as an exchangeable molecule, <strong>capable of transmitting &#8220;messages&#8221;<\/strong> by dynamically and reversibly binding to proteins. The results of these pioneering studies have highlighted new functions for heme, and shown that the heme &#8220;message or signal&#8221; orchestrates diverse and fundamental biological processes in a wide variety of organisms across all kingdoms of life. <\/p>\n\n<p>Our group recently discovered an unprecedented molecular mechanism <strong>by which the heme-oxidative stress axis regulates the activity of an E3 ubiquitin ligase<\/strong> to control the degradation of a heme-sensing transcription factor. We revealed how genetic mutations in this pathway in <strong>lung cancer<\/strong> patients critically support tumor progression. <\/p>\n\n<p>The research carried out in our laboratory today is moving in unexplored directions, which may lead us to understand the fundamental mechanisms of cell biology and design new strategies to <strong>advance cancer therapeutics<\/strong>.<\/p>\n\n<p><a href=\"https:\/\/www.lignittolab.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Team website<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/louis-reed-equipe-heme-ubiquitine-cancer-du-poumon-scaled.jpg\" alt=\"Louis Reed team heme, ubitiquitin lung cancer - Centre de recherche en canc&#xE9;rologie de Marseille\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">The projects<\/h2>\n\n<p>Heme and protein degradation<\/p>\n\n<p>Heme and transcription<\/p>\n\n<p>Heme and cancer<\/p>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/welcome-josephine-shabani-to-our-team\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/Josephine_Shabani.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/lignitto-team\/welcome-josephine-shabani-to-our-team\/\">Welcome Josephine Shabani to our team!<\/a><\/h4>\n\n<p>We are delighted to welcome Josephine Shabani, a Master 2 student at the University of Verona (Italy), who has recently joined our team.<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/scientific-publication\/lignitto-team-deciphers-bach1-degradation-mechanisms-under-oxidative-stress\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/02\/Cao-et-aal-2024.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/scientific-publication\/lignitto-team-deciphers-bach1-degradation-mechanisms-under-oxidative-stress\/\">New publication: Deciphering the mechanisms of BACH1 degradation under oxidative stress<\/a><\/h4>\n\n<p>We are delighted to announce the publication of our latest article in <em>Cell<\/em>. This work, carried out in collaboration with several research teams, explores how two distinct E3 ligases recognize and target the quaternary degrons of BACH1 in response to oxidative stress. <\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/category\/crcm-articles\/\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>06\/2024<\/p>\n\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.06.03.594717v1\" target=\"_blank\" rel=\"noreferrer noopener\">Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress. <\/a><\/p>\n\n<p>Cao S, Shi H, Garcia SF, Kito Y, Shi H, Goldberg HV, Ponce J, Ueberheide B, Lignitto L, Pagano M, Zheng N.<\/p>\n\n<p>04\/2021<\/p>\n\n<p><a href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2023157118\" target=\"_blank\" rel=\"noreferrer noopener\">ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. <\/a><\/p>\n\n<p>Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O&#8217;Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ.<\/p>\n\n<p>03\/2021<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/developmental-cell\/fulltext\/S1534-5807(21)00123-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580721001234%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">Linking ubiquitin to actin dynamics during cell fusion. <\/a><\/p>\n\n<p>Lignitto L, Pagano M.<\/p>\n\n<p>07\/2019<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(19)30631-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419306312%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. <\/a><\/p>\n\n<p>Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M.<\/p>\n\n<p>05\/2013<\/p>\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/ncomms2791\" target=\"_blank\" rel=\"noreferrer noopener\">Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. <\/a><\/p>\n\n<p>Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L&#8217;Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A.<\/p>\n\n<p>04\/2011<\/p>\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/ncb2209\" target=\"_blank\" rel=\"noreferrer noopener\">Control of PKA stability and signalling by the RING ligase praja2. <\/a><\/p>\n\n<p>Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nistic\u00f2 R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A.<\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=(Lignitto%20L%5BAuthor%5D)%20AND%20((CRCM%5BAffiliation%5D)%20OR%20(Centre%20de%20Recherche%20en%20Cance%CC%81rologie%20de%20Marseille%5BAffiliation%5D)%20OR%20(Cancer%20Research%20Center%20of%20Marseille%5BAffiliation%5D))&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.fondation-arc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/canceropole-paca.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/anr.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/magdalini_bourazani_crcm.jpg\" alt=\"Magdalini Bourazani CRCM\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Magdalini Bourazani<\/h5>\n\n<h5 class=\"wp-block-heading\">Master 1 student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/yu_ying_yang_crcm.jpg\" alt=\"Yu Ying Yang - Marseille Cancer Research Center\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Yu Ying Yang<\/h5>\n\n<h5 class=\"wp-block-heading\">Master 2 student<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/heme-ubiquitin-and-lung-cancer-team-comet-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a> &amp; <a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Heme, Ubiquitin and Lung Cancer Paoli Calmettes Institute Luca Lignitto Team manager Jack Jordan<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5872,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5882","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - 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