{"id":5874,"date":"2024-11-26T16:00:59","date_gmt":"2024-11-26T15:00:59","guid":{"rendered":"https:\/\/crcm-marseille.fr\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/"},"modified":"2026-01-15T09:22:18","modified_gmt":"2026-01-15T08:22:18","slug":"epithelial-stem-cells-and-cancer","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer\/","title":{"rendered":"Epithelial Stem Cells and Cancer"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-comet-crcm-1024x622.png\" alt=\"Comet department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h1 class=\"wp-block-heading\">Epithelial stem cells and cancer<\/h1>\n\n<p>Paoli Calmettes Institute<\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/x.com\/chrisginestier\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/logo-x-equipe-crcm.png\" alt=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/emmanuelle-charafe\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/emmauelle_charafe_crcm_2.jpg\" alt=\"Emmanuelle Charafe - Epithelial Stem Cells and Cancer Team - ICEP CRCM Experimental Histopathology Platform\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/emmanuelle-charafe\/\">Emmanuelle Charafe<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-ginestier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/christophe-ginestier-crcm.jpg\" alt=\"Christophe Ginestier - Epithelial stem cells and cancer team - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/christophe-ginestier\/\">Christophe Ginestier<\/a><\/p>\n\n<p>Team manager<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/shuheng-lin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/shuheng-lin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lin_shuheng_crcm.jpg\" alt=\"Shuheng Lin - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Shuheng Lin<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-chevrier\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-chevrier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/chevrier_veronique_crcm.jpg\" alt=\"V&#xE9;ronique Chevrier - CRCM - 3D-Hub-O platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">V\u00e9ronique Chevrier<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/zeinab-homayed\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/zeinab-homayed\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/homayed_zeinab_crcm.jpg\" alt=\"Zeinab Homayed CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Zeinab Homayed<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/agnes-tallet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/agnes-tallet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/tallet_agnes_crcm.jpg\" alt=\"Agn&#xE8;s Tallet - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Agnes Tallet<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/anais-grandon\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/anais-grandon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/grandon_anais_crcm.jpg\" alt=\"Ana&#xEF;s Grandon - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Ana\u00efs Grandon<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/caroline-bonnet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/caroline-bonnet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/bonnet_caroline_crcm.jpg\" alt=\"Caroline Bonnet - CRCM - TrGET platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Caroline Bonnet<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/chloe-petitpas\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/chloe-petitpas\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/petitpas_chloe_crcm.jpg\" alt=\"Chlo&#xEB; Petitpas - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Chlo\u00e9 Petitpas<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/emma-der-kazarian\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/emma-der-kazarian\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/der_kazarian_emma_crcm.jpg\" alt=\"Emma Der Kazarian - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Emma Der Kazarian<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/geraldine-guasch\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/geraldine-guasch\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/guasch_geraldine_crcm.jpg\" alt=\"Guasch Geraldine Epithelial stem cells and cancer CRCM - 3D-Hub-O platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">G\u00e9raldine Guasch<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/julien-wicinski\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/julien-wicinski\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/wicinski_julien_crcm.jpg\" alt=\"Julien Wicinski - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Julien Wicinski<\/h2>\n\n<h4 class=\"wp-block-heading\">Technician<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/marjorie-martin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/marjorie-martin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/martin_marjorie_crcm.jpg\" alt=\"Marjorie Martin - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Marjorie Martin<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/min-wu\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/min-wu\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/min_wu_crcm.jpg\" alt=\"Min Wu - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Min Wu<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/olivier-rosnet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/olivier-rosnet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/rosnet_olivier_crcm.jpg\" alt=\"Olivier Rosnet - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Olivier Rosnet<\/h2>\n\n<h4 class=\"wp-block-heading\">Researcher<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/shuheng-lin\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/shuheng-lin\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/lin_shuheng_crcm.jpg\" alt=\"Shuheng Lin - Epithelial Stem Cells and Cancer Team - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Shuheng Lin<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-chevrier\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/veronique-chevrier\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/chevrier_veronique_crcm.jpg\" alt=\"V&#xE9;ronique Chevrier - CRCM - 3D-Hub-O platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">V\u00e9ronique Chevrier<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/zeinab-homayed\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/zeinab-homayed\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/homayed_zeinab_crcm.jpg\" alt=\"Zeinab Homayed CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Zeinab Homayed<\/h2>\n\n<h4 class=\"wp-block-heading\">Post-Doctoral Fellow<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/agnes-tallet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/agnes-tallet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/tallet_agnes_crcm.jpg\" alt=\"Agn&#xE8;s Tallet - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Agnes Tallet<\/h2>\n\n<h4 class=\"wp-block-heading\">Hospital Practitioner<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/anais-grandon\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/anais-grandon\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/grandon_anais_crcm.jpg\" alt=\"Ana&#xEF;s Grandon - CRCM\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Ana\u00efs Grandon<\/h2>\n\n<h4 class=\"wp-block-heading\">Doctoral student<\/h4>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/caroline-bonnet\/\"><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/team\/caroline-bonnet\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/bonnet_caroline_crcm.jpg\" alt=\"Caroline Bonnet - CRCM - TrGET platform\"\/><\/a><\/figure>\n\n<h2 class=\"wp-block-heading\">Caroline Bonnet<\/h2>\n\n<h4 class=\"wp-block-heading\">Engineer<\/h4>\n\n<h2 class=\"wp-block-heading\">The Epithelial Stem Cells and Cancer team deciphers intra-tumoral heterogeneity during the various stages of carcinogenesis, from tumor initiation to metastasis, in order to prevent or circumvent therapeutic resistance.<\/h2>\n\n<p><strong>Our understanding of cancer<\/strong> is being transformed by the exploration of clonal diversity, cellular plasticity, drug resistance, and the spatial and temporal evolution of tumors. It is now well accepted that tumors are guided by an evolutionary process, driven at the cellular level by <strong>genetic and epigenetic alterations<\/strong>. This evolution generates <strong>intra-tumoral heterogeneity<\/strong>, which explains both tumor progression and therapeutic resistance.  <\/p>\n\n<p><strong>Objectives of our project<\/strong><br\/>Our team project aims to better understand intra-tumor heterogeneity in order to abolish tumor progression, by :<\/p>\n\n<ol class=\"wp-block-list\">\n<li><strong>Intercepting<\/strong> the source of tumor heterogeneity in the early phases of oncogenesis.<\/li>\n\n\n\n<li><strong>Understanding<\/strong> the dynamics of transition between cellular states to overcome therapeutic resistance.<\/li>\n\n\n\n<li><strong>Characterizing<\/strong> the influence of the microenvironment on cell plasticity.<\/li>\n<\/ol>\n\n<p><strong>Methodology<\/strong><br\/>To answer these questions, we will use the scientific expertise of various team members in two tissue models:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>The <strong>human mammary gland<\/strong><\/li>\n\n\n\n<li>The <strong>anorectal transition zone<\/strong><\/li>\n<\/ul>\n\n<p><strong>Breast cancer program<\/strong><br\/>Our team has pioneered the discovery and <strong>characterization of normal and cancer stem cells<\/strong> from the mammary epithelium<em>(Ginestier et al., Cell Stem Cell, 2007; Charafe-Jauffret et al., Cancer Res., 2009; Morel et al., Nature Med, 2017<\/em>).<\/p>\n\n<p>We are continuing our efforts by developing research projects aimed at deciphering the molecular mechanisms regulating cellular plasticity. The aim is to identify new therapeutic targets and develop therapies to intercept the early phases of oncogenesis and identify vulnerabilities in the cellular states that sustain disease progression (tumor relapse, metastasis). <\/p>\n\n<p>All these research programs are part of a <strong>translational research<\/strong> strategy that includes the development of innovative tools:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Functional screen<\/strong><\/li>\n\n\n\n<li><strong>Primary tumor xenograft bank<\/strong><\/li>\n\n\n\n<li><strong>Lineage tracing<\/strong><\/li>\n\n\n\n<li><strong>Organoid culture<\/strong><\/li>\n\n\n\n<li><strong>scOMICs<\/strong> and <strong>spatial-OMICS<\/strong><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/bandeau-image-equipe-cellules-souches-epitheliales-et-cancer-crcm.jpg\" alt=\"Bandeau images Epithelial stem cells and cancer team - CRCM\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">The projects<\/h2>\n\n<p>Breast Cancer Program<\/p>\n\n<p>Epithelial Transition Zone Program<\/p>\n\n<h2 class=\"wp-block-heading\">Team news<\/h2>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/christophe-ginestier-wins-a-ruban-rose-grant\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Ginestier-News-1.jpg\" alt=\"\"\/><\/a><\/figure>\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/en\/team-charafe-ginestier\/christophe-ginestier-wins-a-ruban-rose-grant\/\">Christophe Ginestier wins a Ruban Rose grant<\/a><\/h4>\n\n<p>Dr Christophe Ginestier receives a \u20ac200,000 Pink Ribbon Award for his project on breast cancer treatment resistance, aimed at identifying new therapies to prevent recurrence.<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/equipe-nunes-devillier\/ils-ont-fait-partie-de-lequipe\/\" target=\"_blank\" rel=\"noreferrer noopener\">All our news<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">front-page publications<\/h2>\n\n<p>06\/2022<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(22)00532-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422005323%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation. <\/a><\/p>\n\n<p>Richart L, Picod-Chedotel ML, Wassef M, Macario M, Aflaki S, Salvador MA, H\u00e9ry T, Dauphin A, Wicinski J, Chevrier V, Pastor S, Guittard G, Le Cam S, Kamhawi H, Castellano R, Guasch G, Charafe-Jauffret E, Heard E, Margueron R, Ginestier C.<\/p>\n\n<p>05\/2021<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-021-23034-x\" target=\"_blank\" rel=\"noreferrer noopener\">A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration. <\/a><\/p>\n\n<p>Mitoyan L, Chevrier V, Hernandez-Vargas H, Ollivier A, Homayed Z, Pannequin J, Poizat F, De Biasi-Cador C, Charafe-Jauffret E, Ginestier C, Guasch G.<\/p>\n\n<p>10\/2019<\/p>\n\n<p><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201809930\" target=\"_blank\" rel=\"noreferrer noopener\">A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells. <\/a><\/p>\n\n<p>Arfaoui A, Rioualen C, Azzoni V, Pinna G, Finetti P, Wicinski J, Josselin E, Macario M, Castellano R, L\u00e9onard-Stumpf C, Bal A, Gros A, Lossy S, Kharrat M, Collette Y, Bertucci F, Birnbaum D, Douik H, Bidaut G, Charafe-Jauffret E, Ginestier C.<\/p>\n\n<p>02\/2017<\/p>\n\n<p><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(17)30181-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112471730181X%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noreferrer noopener\">miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling. <\/a><\/p>\n\n<p>Jo S, Das S, Williams A, Chretien AS, Pagliardini T, Le Roy A, Fernandez JP, Le Clerre D, Jahangiri B, Chion-Sotinel I, Rozlan S, Dessez E, Gouble A, Duss\u00e9aux M, Galetto R, Duclert A, Marcenaro E, Devillier R, Olive D, Duchateau P, Poirot L, Valton J.<\/p>\n\n<p>05\/2017<\/p>\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/nm.4323\" target=\"_blank\" rel=\"noreferrer noopener\">A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability. <\/a><\/p>\n\n<p>Morel AP, Ginestier C, Pommier RM, Cabaud O, Ruiz E, Wicinski J, Devouassoux-Shisheboran M, Combaret V, Finetti P, Chassot C, Pinatel C, Fauvet F, Saintigny P, Thomas E, Moyret-Lalle C, Lachuer J, Despras E, Jauffret JL, Bertucci F, Guitton J, Wierinckx A, Wang Q, Radosevic-Robin N, Penault-Llorca F, Cox DG, Hollande F, Ansieau S, Caramel J, Birnbaum D, Vigneron AM, Tissier A, Charafe-Jauffret E, Puisieux A.<\/p>\n\n<p>02\/2017<\/p>\n\n<p><a href=\"https:\/\/elifesciences.org\/articles\/22914\" target=\"_blank\" rel=\"noreferrer noopener\">De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGF\u03b2-deficient squamous cell carcinoma from transition zones. <\/a><\/p>\n\n<p>McCauley HA, Chevrier V, Birnbaum D, Guasch G.<\/p>\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%28Charafe-jauffret+E%5BAuthor%5D%29+OR+%28Ginestier+C%5BAuthor%5D%29%29+AND+%28%28CRCM%5BAffiliation%5D%29+OR+%28Centre+de+Recherche+en+Cance%CC%81rologie+de+Marseille%5BAffiliation%5D%29+OR+%28Cancer+Research+Center+of+Marseille%5BAffiliation%5D%29%29\" target=\"_blank\" rel=\"noreferrer noopener\">All our publications<\/a><\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/forme-gris-equipe-gauche-crcm.png\" alt=\"Grey form equpe CRCM\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/09\/formes-equipe-droite-crcm.png\" alt=\"Form CRCM team\"\/><\/figure>\n\n<h2 class=\"wp-block-heading\">Labels, Funding and Partners<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/anr.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/provence.gefluc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.institutpaolicalmettes.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/anr.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/provence.gefluc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.institutpaolicalmettes.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.univ-amu.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.e-cancer.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ligue-cancer.net\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/anr.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/provence.gefluc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n<p>Alumni<\/p>\n\n<p>Like others, they were part of the team.<br\/>Thanks to all those who contributed to CRCM&#8217;s excellence and impact.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/salvador_marion_crcm-1.jpg\" alt=\"Salvador Marion alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Marion Salvador<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral Fellow, Universit\u00e4t Basel,<br\/>Basel, Switzerland, CRCM Doctoral Fellow<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/el_helou_rita_crcm-1.jpg\" alt=\"El Helou Rita alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Rita El Helou<\/h5>\n\n<h5 class=\"wp-block-heading\">General Manager, Diagnostic Innovative Systems,<br\/>Dubai, UAE, Doctoral student at CRCM<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/azzoni_violette_crcm-1.jpg\" alt=\"Azzoni Violette alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Violette Azzoni<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral fellow, Biotech Research and Innovation Centre,<br\/>Copenhagen, Denmark, Doctoral student at CRCM<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/forissier_violaine_crcm-1.jpg\" alt=\"Forissier Violaine alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Violaine Forissier<\/h5>\n\n<h5 class=\"wp-block-heading\">Oncologist\/radiotherapist, Bonneveine Clinic,<br\/>Marseille, France, Doctoral student at the CRCM<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/picod_mary_loup_crcm-1.jpg\" alt=\"Picod Mary Loup alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Mary-Loup Picod<\/h5>\n\n<h5 class=\"wp-block-heading\">Kinesiologist,<br\/>Grans, France, Doctoral student at CRCM<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/mitoyan_loucine_crcm-1.jpg\" alt=\"Mitoyan Loucine alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Loucine Mitoyan<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral fellow, Universit\u00e9 libre de Bruxelles,<br\/>Brussels, Belgium, CRCM doctoral student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/castagne_martin_crcm-1.jpg\" alt=\"Castagne martin alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Martin Castagn\u00e8<\/h5>\n\n<h5 class=\"wp-block-heading\">Medical student, Paris-Sorbonne University,<br\/>Paris, France, PhD student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/rouault_celia_crcm-1.jpg\" alt=\"Rouault Celia alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">C\u00e9lia Rouault<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral Fellow, Washington University,<br\/>Saint Louis, USA, Ph.<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/vedelago_mauro_crcm-1.jpg\" alt=\"Vedelago Mauro alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Mauro Vedelago<\/h5>\n\n<h5 class=\"wp-block-heading\">Postdoctoral fellow, Oncolille,<br\/>Lille, France, Doctoral student<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/macario_manon_crcm-1.jpg\" alt=\"Macario Manon alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Manon Macario<\/h5>\n\n<h5 class=\"wp-block-heading\">Project Manager, Transcure Bioservices,<br\/>Saint-Julien-en-Genevois, France, IE<\/h5>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/11\/ollivier_alexane_crcm-1.jpg\" alt=\"Ollivier Alexane alumnis Epithelial stem cells and cancer team Translate-it CRCM department\"\/><\/figure>\n\n<h5 class=\"wp-block-heading\">Alexane Ollivier<\/h5>\n\n<h5 class=\"wp-block-heading\">Lab Technician, Centre for Genomic Regulation,<br\/>Barcelona, Spain, IE<\/h5>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bsky.app\/profile\/crcm.bsky.social\" target=\"_blank\" rel=\"noreferrer noopener\">Bluesky<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/epithelial-stem-cells-and-cancer-team-comet-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; Created by <a href=\"https:\/\/yesss-communication.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yesss Communication<\/a> &amp; <a href=\"https:\/\/www.bioself-communication.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bioself<\/a><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epithelial stem cells and cancer Paoli Calmettes Institute Emmanuelle Charafe Team manager Christophe Ginestier<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5872,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5874","page","type-page","status-publish","hentry"],"yoast_head":"<!-- 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