{"id":5872,"date":"2024-11-21T09:29:08","date_gmt":"2024-11-21T08:29:08","guid":{"rendered":"https:\/\/crcm-marseille.fr\/comet-department\/"},"modified":"2026-01-14T14:09:02","modified_gmt":"2026-01-14T13:09:02","slug":"comet-department","status":"publish","type":"page","link":"https:\/\/crcm-marseille.fr\/en\/comet-department\/","title":{"rendered":"Comet Department"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-centre-de-recherche-en-cancerologie-de-marseille-crcm.webp#847\" alt=\"Logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<ul id=\"menu-menu-principal\" class=\"wp-block-list\">\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Home<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\">Our center<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\">Our research<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\">For students<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\">For scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\">Research teams<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/#\"><\/a><\/li>\n<\/ul>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-comet-picto-crcm_2.png\" alt=\"Comet picto CRCM logo\"\/><\/figure>\n\n<h1 class=\"wp-block-heading\">Comet<\/h1>\n\n<p>The CoMET department, headed by <strong>Drs Sophie Vasseur and Christophe Ginestier,<\/strong> brings together six research teams dedicated to understanding the mechanisms of cancer cell survival, plasticity, dissemination and resistance. By integrating the <strong>tumor microenvironment<\/strong>, this work aims to discover targets for new therapies. <\/p>\n\n<p>CoMET has some sixty members exploring the<strong>tumor ecosystem<\/strong>, with a focus on tumor metabolism, intercellular communication and intratumoral heterogeneity. Four major initiatives, <strong>3D-Hub-O, ST-omics, CEEVEC, and Met&#8217;Connect, are<\/strong> developing new tools and models (Organoids, Spatial-omics, extracellular vesicles) to decipher the interaction between cells and the impact on cellular and metabolic reprogramming. <\/p>\n\n<p>The ultimate goal is to offer <strong>innovative clinical tools<\/strong> to improve the <strong>therapeutic management<\/strong> of cancer patients.<\/p>\n\n<h2 class=\"wp-block-heading\">Department teams<\/h2>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/jean-paul-borg\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Jean-Paul-Borg.jpg\" alt=\"Jean-Paul Borg team Targeting signalling networks and the microenvironment in cancer - CRCM Proteomics and Mass Spectrometry Platform\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/flavio-maina\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/Flavio-Maina.jpg\" alt=\"Flavio Maina Team Targeting signaling networks and the microenvironment in cancer - CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/jean-paul-borg\/\">Jean-Paul Borg<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/flavio-maina\/\">Flavio Maina<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/departement-comet\/equipe-ciblage-des-reseaux-de-signalisation-et-du-microenvironnement-dans-le-cancer-departement-comet\/\"><strong>Targeting signalling networks and the microenvironment in cancer<\/strong><\/a><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/sophie-vasseur\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/vasseur_sophie_crcm.webp?ver=1737448409\" alt=\"Sophie Vasseur CRCM - Stromal Cell Dialogue team\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/richard-tomasini\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/crcm_tomasini_richard.jpg\" alt=\"Richard Tomasini CRCM - Stromal Cell Dialogue team\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/sophie-vasseur\/\">Sophie Vasseur<\/a><\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/richard-tomasini\/\">Richard Tomasini<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-comet\/equipe-dialogue-cellules-stromales-tumorales-et-reprogrammation-metabolique-dans-les-cancers-du-pancreas-departement-comet\/\">Stromal\/tumoral cell dialogue and metabolic reprogramming in pancreatic cancer<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/frederic-bard\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/bard_frederic_crcm_new.webp\" alt=\"\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/frederic-bard\/\">Fr\u00e9d\u00e9ric Bard<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-comet\/equipe-glycosylation-interfaces-cellulaires-et-therapies-departement-comet\/\">Glycosylation, cell interfaces and therapies<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/luca-lignitto\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2025\/01\/lignitto_luca_crcm.jpg?ver=1737387804\" alt=\"Lignitto Lucas - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/luca-lignitto\/\">Luca Lignitto<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-comet\/equipe-heme-ubiquitine-et-cancer-du-poumon-departement-comet\/\">Heme, Ubiquitin and Lung Cancer<\/a><\/strong><\/p>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/team\/pascale-zimmermann\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/zimmermann_pascale_crcm_2.jpg?ver=1737448871\" alt=\"Pascale Zimmermann CRCM\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/team\/pascale-zimmermann\/\">Pascale Zimmermann<\/a><\/p>\n\n<p><strong><a href=\"https:\/\/crcm-marseille.fr\/departement-comet\/equipe-vesicules-extracellulaires-mecanismes-de-signalisation-et-ingenierie-therapeutique-departement-comet\/\">Extracellular vesicles: signaling mechanisms and therapeutic engineering<\/a><\/strong><\/p>\n\n<h3 class=\"wp-block-heading\">The news<\/h3>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/interview-with-rima-kochman-doctoral-student-in-the-coulon-team\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/article-interview-rima-kochman-doctorante-crcm.jpg\" alt=\"Article interview with Rima Kochman doctoral student - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/interview-de-rima-kochman-doctorante-au-sein-de-lequipe-coulon\/\">Interview with Rima Kochman, doctoral student in the Coulon team<\/a><\/h5>\n\n<p>Rima Kochman from the Coulon team was one of the doctoral students who stood out with her thesis project. &#8220;Heterozygous RPA2 variant [&#8230;] <\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/crcm-marseille.fr\/en\/crcm-articles\/more-than-26-articles-published-in-just-a-few-months-by-crcm-teams\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/12\/publications-scientifiques-crcm.jpg\" alt=\"Scientific publications - Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/crcm-marseille.fr\/toutes-les-categories\/articles-crcm\/plus-de-26-articles-publies-en-quelques-mois-par-les-equipes-crcm\/\">More than 26 articles published in just a few months by CRCM teams!<\/a><\/h5>\n\n<p>Once again, CRCM members have been very productive, with no fewer than 26 articles published [&#8230;].<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">SEE MORE<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">The events<\/h3>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">see more<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">our other areas of research<\/h3>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-ohio\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-ohio-crcm.png\" alt=\"Logo Ohio department Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-translate-it\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-translate-it-crcm-1.png#846\" alt=\"\" title=\"\"\/><\/a><\/figure>\n\n<figure class=\"wp-block-image\"><a class=\"\" href=\"https:\/\/crcm-marseille.fr\/departement-genome-integrity\/\"><img decoding=\"async\" src=\"https:\/\/crcm-marseille.fr\/wp-content\/uploads\/2024\/10\/logo-departement-genome-integrity-crcm.png\" alt=\"Genome Integrity department logo Marseille Cancer Research Center\"\/><\/a><\/figure>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Intranet connection<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/directory\/\">Directory<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">About IPC<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/news\/\">News<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/evenements\/\">Events<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Legal notice<\/a><br\/><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Privacy policy<\/a><\/p>\n\n<h3 class=\"wp-block-heading\">Marseille Cancer Research Center<\/h3>\n\n<p>27 Bd Le\u00ef Roure, CS 30059<br\/>13273 Marseille Cedex 09<\/p>\n\n<p>Tel: 04 86 97 72 00<\/p>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/\">Contact us<br\/>How to get here<\/a><\/p>\n\n<p>Follow us<\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/x.com\/crcm_marseille\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/@CRCM-marseille\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/company\/crcm-marseille\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a><\/li>\n<\/ul>\n\n<p><a href=\"https:\/\/crcm-marseille.fr\/en\/comet-department\/\"><\/a><\/p>\n\n<p>www.crcm-marseille.fr \u00a92024 | All rights reserved &#8211; 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[\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"class_list":["post-5872","page","type-page","status-publish","hentry"],"yoast_head":"<!-- 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